SCYL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCYL2_MOUSE
• UniProt AC: Q8CFE4
• Protein Name: SCY1-like protein 2
• Gene Name: Scyl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 930
• Subcellular Localization: Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Plasma membrane-associated in clathrin-coated vesicles. Colocalizes to the trans-Golgi network (TGN) and to
• Protein Description: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. May be a serine/threonine-protein kinase. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (By similarity)..
• Protein Sequence: MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENVILNKSGAWKIMGFDFCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNQGRPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYIKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFSSFIAVIKEMLSRLESEHRTKLEQLHVMQEQQRSLDIGNQMSTSEETKVAHSGSQQIDKVFNNIGADLLSGSESENREDGMQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPIAPIKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTPVPSTGLGMMFSTPIDNTKRNLTNGLNANMGFQTSGFSMPVNPNQNFFSGTGTAGVTTMSLGAPPTMSNFSPLTIPPASVKQPQQRPTDMSALNNLFGPQKPKVSMNQLSQQKPNQWLNQFAPPQGSPVMGSAAMGTQGNVMGQAAFGMQGNPFFNPQNFAQPPPTTMTSSSSASNDLKDLFG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MESMLNKLKSTVTK -CHHHHHHHHHHHHH	54.02	22790023
13	Phosphorylation	NKLKSTVTKVTADVT HHHHHHHHHHHHHCH	21.64	22817900
29	Phosphorylation	AVMGNPVTREFDVGR HHCCCCCEEEEECCC	26.24	22817900
219 (in isoform 2)	Phosphorylation	-	24.25	30352176
234 (in isoform 2)	Phosphorylation	-	8.25	29514104
290	Phosphorylation	DQLSRLGSSSLTSIP HHHHHHCCCCCCCCC	22.73	29899451
291	Phosphorylation	QLSRLGSSSLTSIPE HHHHHCCCCCCCCCH	27.80	29899451
292	Phosphorylation	LSRLGSSSLTSIPEE HHHHCCCCCCCCCHH	37.05	29472430
294	Phosphorylation	RLGSSSLTSIPEEVR HHCCCCCCCCCHHHH	26.93	29472430
295	Phosphorylation	LGSSSLTSIPEEVRE HCCCCCCCCCHHHHH	41.25	29472430
313	Phosphorylation	LLLNVTPTVRPDADQ HHHHCCCCCCCCHHH	21.56	21183079
322	Phosphorylation	RPDADQMTKIPFFDD CCCHHHHCCCCCCCC	21.86	22817900
622	Phosphorylation	VMQEQQRSLDIGNQM HHHHHHHHCCCCCCC	26.51	22817900
640	Phosphorylation	EETKVAHSGSQQIDK HHHHCCCCCHHHHHH	30.33	29899451
642	Phosphorylation	TKVAHSGSQQIDKVF HHCCCCCHHHHHHHH	23.17	27841257
658	Phosphorylation	NIGADLLSGSESENR HHCHHHHCCCCCCCC	47.79	19144319
660	Phosphorylation	GADLLSGSESENRED CHHHHCCCCCCCCCC	34.28	26643407
662	Phosphorylation	DLLSGSESENREDGM HHHCCCCCCCCCCCC	41.70	26643407
677	Phosphorylation	QGKQKRGSLTLEEKQ CCCHHHCCCCHHHHH	23.39	25521595
679	Phosphorylation	KQKRGSLTLEEKQKL CHHHCCCCHHHHHHH	33.54	28833060
708	Phosphorylation	PLKPQVHTPIAPIKQ CCCCCCCCCCCCCCC	19.96	26643407
741	O-linked_Glycosylation	SVSTPKISASSTFTP EECCCCCCCCCCCEE	28.37	30059200

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCYL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCYL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCYL2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SCYL2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677, AND MASSSPECTROMETRY.
PubMed: 19144319

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677, AND MASSSPECTROMETRY.
PubMed: 19367708