dbPTM

SRBP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRBP2_MOUSE
UniProt AC	Q3U1N2
Protein Name	Sterol regulatory element-binding protein 2
Gene Name	Srebf2 {ECO:0000312\|MGI:MGI:107585}
Organism	Mus musculus (Mouse).
Sequence Length	1130
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane Multi-pass membrane protein . Moves from the endoplasmic reticulum to the Gol
Protein Description	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes..
Protein Sequence	MDESSELGVLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGGGSNGGSGNNSSGRGNNGGATDPAVQRSFSQVPLSTFSPSAASPQAPALQVKVSPTPPRATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSPQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQLDPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNTDQHPYSGSGRSVLSLESGAGGWFDWMVPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRPSVTFWRHRKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKILPSTLIEIHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCGPEHSTVPDSLRWLCHPLGQKFFMERSWSIKSAAKESLYCAQRSPADPIAQVHQAFCKNLLERAVESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGFVTSPFSSSSVLRSALGPDVICRWWTSAVTMAISWLQGDDAAVRSRFTEVERVPKALEVTESPLVKAVFYTCRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVIQLFTCDLLLSLRTALWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRPTQNTKHGEVDTWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SELGVLETMETLTEL HHHHHHHHHHHHHHH	19.02	-
15	Phosphorylation	GVLETMETLTELGDE HHHHHHHHHHHHCCC	28.32	-
17	Phosphorylation	LETMETLTELGDELT HHHHHHHHHHCCCCC	36.26	-
94	Phosphorylation	QVPLSTFSPSAASPQ CCCHHHCCCCCCCCC	20.31	26643407
96	Phosphorylation	PLSTFSPSAASPQAP CHHHCCCCCCCCCCC	34.96	26643407
99	Phosphorylation	TFSPSAASPQAPALQ HCCCCCCCCCCCCEE	19.77	26643407
110	Phosphorylation	PALQVKVSPTPPRAT CCEEEEECCCCCCCC	19.82	26643407
112	Phosphorylation	LQVKVSPTPPRATPV EEEEECCCCCCCCCC	38.12	26643407
239	Phosphorylation	VQPQIIKTDSLVLTT ECCEEEECCEEEEEE	22.03	28066266
241	Phosphorylation	PQIIKTDSLVLTTLK CEEEECCEEEEEEEE	26.13	28066266
323	Phosphorylation	KEGERRTTHNIIEKR CCCCCCCHHHHHHHH	15.89	-
334	Phosphorylation	IEKRYRSSINDKIIE HHHHHHHHHCCHHHH	19.20	25338131
404	Phosphorylation	DLGSLVDSDVDLKID CHHHHCCCCCCCCCC	31.86	28066266
458	Phosphorylation	KVKDEPDSPPVALGM CCCCCCCCCCCHHCC	41.65	26745281
701	Phosphorylation	EEKILPSTLIEIHLT HHHCCCHHHHHHHHH	29.80	27357545
708	Phosphorylation	TLIEIHLTAAMGLKT HHHHHHHHHHCCCCC	9.75	27357545
715	Phosphorylation	TAAMGLKTRCGGKLG HHHCCCCCCCCCHHH	35.91	27357545
780	Phosphorylation	SLYCAQRSPADPIAQ HHHHHCCCCCCHHHH	16.62	24719451
848	Phosphorylation	GFVTSPFSSSSVLRS CCCCCCCCCHHHHHH	32.47	23984901
849	Phosphorylation	FVTSPFSSSSVLRSA CCCCCCCCHHHHHHH	27.32	23984901
850	Phosphorylation	VTSPFSSSSVLRSAL CCCCCCCHHHHHHHH	24.22	23984901
851	Phosphorylation	TSPFSSSSVLRSALG CCCCCCHHHHHHHHC	27.41	23984901
903	Phosphorylation	KALEVTESPLVKAVF CHHHCCCCHHHHHHH	17.73	20139300
1035	Phosphorylation	VRLMAGASPTRTHQL HHHHCCCCCCHHHHH	26.36	28066266
1037	Phosphorylation	LMAGASPTRTHQLLE HHCCCCCCHHHHHHH	45.78	28066266
1046	Phosphorylation	THQLLEHSLRRRPTQ HHHHHHHHHHCCCCC	17.75	29514104
1083	Phosphorylation	ACRHLPLSFLSSPGQ HHHCCCHHHHCCHHH	23.38	26643407
1086	Phosphorylation	HLPLSFLSSPGQRAV CCCHHHHCCHHHHHH	32.26	26643407
1087	Phosphorylation	LPLSFLSSPGQRAVL CCHHHHCCHHHHHHH	34.89	26745281
1110	Phosphorylation	EKVGDRRSCSDCQQM HHHCCCCCCHHHHHH	20.90	17242355
1117	Oxidation	SCSDCQQMIVKLGGG CCHHHHHHHHHCCCC	1.24	17242355

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Itch	Q8C863	PMID:25777360

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRBP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRBP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DMRTD_MOUSE	Dmrtc2	physical	20211142

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRBP2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1110, AND MASSSPECTROMETRY.	17242355 [Abstract]