MCCB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCCB_MOUSE
• UniProt AC: Q3ULD5
• Protein Name: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
• Gene Name: Mccc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 563
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism..
• Protein Sequence: MWGALRSALRPCCRAAVPPQRAYHGDSVARLGTQPDSASSTYQENYEQMKALVSQLHERAQYVRLGGSEKARARHTSRGKLLPRDRIDNLIDPGSPFLEFSQFAGYQLYGDEEVPAGGIITGIGRVSGVECMIVANDATVKGGTYYPVTVKKHVRAQEIALQNRLPCIYLVDSGGANLPRQADTFPDRDHFGRIFYNQAIMSSKNITQIAVVMGSCTAGGAYVPAMADENIIVQKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGVTDHYALDDHHALHLTRKVVRSLNYQKKMDVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFNEFKALYGDTLVTGFARIFGYPVGIIGNNGVLFSESAKKGAHFVQLCCQRNIPLLFLQNITGFMVGRDYEAEGIAKDGAKMVAAVACAKVPKITVIIGGSYGAGNYGMCGRAYSPRFLYMWPNARISVMGGEQAATVLATVARDQKAREGKQFSSAEEAALKEPIIKRFEEEGNPYYSSARLWDDGIIDPVDTRLVLGLSLSAALNAPIQRTDFGIFRM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MWGALRSALRPCCR -CCHHHHHHHHHHHH	32.29	22942356
33	Phosphorylation	DSVARLGTQPDSASS CCCCCCCCCCCCCCH	41.33	23984901
37	Phosphorylation	RLGTQPDSASSTYQE CCCCCCCCCCHHHHH	36.41	23984901
39	Phosphorylation	GTQPDSASSTYQENY CCCCCCCCHHHHHHH	27.45	23984901
40	Phosphorylation	TQPDSASSTYQENYE CCCCCCCHHHHHHHH	30.74	23984901
41	Phosphorylation	QPDSASSTYQENYEQ CCCCCCHHHHHHHHH	27.08	23984901
42	Phosphorylation	PDSASSTYQENYEQM CCCCCHHHHHHHHHH	18.77	23984901
46	Phosphorylation	SSTYQENYEQMKALV CHHHHHHHHHHHHHH	13.54	23984901
50	Acetylation	QENYEQMKALVSQLH HHHHHHHHHHHHHHH	37.96	23864654
70	Succinylation	VRLGGSEKARARHTS HHCCCCHHHHHHHCC	44.89	23806337
70	Succinylation	VRLGGSEKARARHTS HHCCCCHHHHHHHCC	44.89	-
70	Glutarylation	VRLGGSEKARARHTS HHCCCCHHHHHHHCC	44.89	24703693
70	Acetylation	VRLGGSEKARARHTS HHCCCCHHHHHHHCC	44.89	23576753
131	S-nitrosylation	GRVSGVECMIVANDA CCCCCCEEEEEECCC	1.78	21278135
131	S-nitrosocysteine	GRVSGVECMIVANDA CCCCCCEEEEEECCC	1.78	-
141	Succinylation	VANDATVKGGTYYPV EECCCEECCCEEEEE	47.47	23806337
141	Succinylation	VANDATVKGGTYYPV EECCCEECCCEEEEE	47.47	-
141	Acetylation	VANDATVKGGTYYPV EECCCEECCCEEEEE	47.47	23806337
167	S-nitrosocysteine	ALQNRLPCIYLVDSG HHHHCCCEEEEECCC	3.65	-
167	S-nitrosylation	ALQNRLPCIYLVDSG HHHHCCCEEEEECCC	3.65	21278135
167	S-palmitoylation	ALQNRLPCIYLVDSG HHHHCCCEEEEECCC	3.65	28526873
256	Phosphorylation	AATGEEVSAEDLGGA CCCCCCCCHHHHCCC	29.26	30352176
267	S-nitrosylation	LGGADLHCRKSGVTD HCCCCCCCCCCCCCC	8.34	22178444
267	S-palmitoylation	LGGADLHCRKSGVTD HCCCCCCCCCCCCCC	8.34	28526873
267	S-nitrosocysteine	LGGADLHCRKSGVTD HCCCCCCCCCCCCCC	8.34	-
326	Succinylation	GIVGANLKRSFDVRE CHHCCCCCCCCCHHH	45.89	23954790
328	Phosphorylation	VGANLKRSFDVREVI HCCCCCCCCCHHHHH	24.98	20139300
342	Phosphorylation	IARIVDGSRFNEFKA HHHHHCCCCHHHHHH	29.27	20139300
420	Acetylation	YEAEGIAKDGAKMVA CCCCCCCCCHHHHHH	55.57	23954790
431	S-nitrosylation	KMVAAVACAKVPKIT HHHHHHHHCCCCCEE	2.79	21278135
431	S-palmitoylation	KMVAAVACAKVPKIT HHHHHHHHCCCCCEE	2.79	28526873
431	S-nitrosocysteine	KMVAAVACAKVPKIT HHHHHHHHCCCCCEE	2.79	-
433	Acetylation	VAAVACAKVPKITVI HHHHHHCCCCCEEEE	59.98	23806337
433	Succinylation	VAAVACAKVPKITVI HHHHHHCCCCCEEEE	59.98	-
433	Succinylation	VAAVACAKVPKITVI HHHHHHCCCCCEEEE	59.98	23806337
495	Malonylation	DQKAREGKQFSSAEE HHHHHCCCCCCHHHH	43.34	26320211
495	Succinylation	DQKAREGKQFSSAEE HHHHHCCCCCCHHHH	43.34	-
495	Succinylation	DQKAREGKQFSSAEE HHHHHCCCCCCHHHH	43.34	23806337
495	Acetylation	DQKAREGKQFSSAEE HHHHHCCCCCCHHHH	43.34	23576753
498	Phosphorylation	AREGKQFSSAEEAAL HHCCCCCCHHHHHHH	26.58	29472430
499	Phosphorylation	REGKQFSSAEEAALK HCCCCCCHHHHHHHC	40.77	29472430
506	Acetylation	SAEEAALKEPIIKRF HHHHHHHCCHHHHHH	57.63	23201123
511	Acetylation	ALKEPIIKRFEEEGN HHCCHHHHHHHHCCC	52.32	23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCCB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCCB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCCB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MCCB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.