MPC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPC2_MOUSE
• UniProt AC: Q9D023
• Protein Name: Mitochondrial pyruvate carrier 2
• Gene Name: Mpc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 127
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Mediates the uptake of pyruvate into mitochondria..
• Protein Sequence: MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWRYNQELKSKGIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Acetylation	TYHRLMDKVELLLPK HHHHHHHHHHHHCCC	24.52	24062335
26	Acetylation	KVELLLPKKLRPLYN HHHHHCCCCHHHCCC	65.49	23576753
26	Ubiquitination	KVELLLPKKLRPLYN HHHHHCCCCHHHCCC	65.49	-
26	Malonylation	KVELLLPKKLRPLYN HHHHHCCCCHHHCCC	65.49	26320211
26	Glutarylation	KVELLLPKKLRPLYN HHHHHCCCCHHHCCC	65.49	24703693
49	Acetylation	FFWAPIMKWGLVCAG EEEHHHHHHHHHHHH	38.54	23576753
49	Succinylation	FFWAPIMKWGLVCAG EEEHHHHHHHHHHHH	38.54	24315375
54	S-nitrosocysteine	IMKWGLVCAGLADMA HHHHHHHHHHHHHHC	2.75	-
78	Phosphorylation	QSTVLMATGFIWSRY HHHHHHHHHCCCEEE	20.75	25293948
83	Phosphorylation	MATGFIWSRYSLVII HHHHCCCEEEEEEEE	19.27	25293948
109	Phosphorylation	FVGSAGASQLFRIWR ECCCCCHHHHHHHHH	26.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MPC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-19, AND MASS SPECTROMETRY.
PubMed: 16916647