ODO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ODO1_MOUSE
• UniProt AC: Q60597
• Protein Name: 2-oxoglutarate dehydrogenase, mitochondrial
• Gene Name: Ogdh
• Organism: Mus musculus (Mouse).
• Sequence Length: 1023
• Subcellular Localization: Mitochondrion matrix . Nucleus . Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
• Protein Description: 2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A..
• Protein Sequence: MFHLRTCAAKLRPLTASQTVKTFSQNKPAAIRTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLSLSRSSLATMAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLHESDLDKVFHLPTTTFIGGQEPALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDMSSANGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDMKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRNTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFTRSKDEKILHIKHWLDSPWPGFFTLDGQPRSMTCPSTGLEEDVLFHIGKVASSVPVENFTIHGGLSRILKTRRELVTNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFNNMAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLQEENFDINQLYDCNWIVVNCSTPGNFFHVLRRQILLPFRKPLIVFTPKSLLRHPEARTSFDEMLPGTHFQRVIPENGPAAQDPHKVKRLLFCTGKVYYDLTRERKARNMEEEVAITRIEQLSPFPFDLLLKEAQKYPNAELAWCQEEHKNQGYYDYVKPRLRTTIDRAKPVWYAGRDPAAAPATGNKKTHLTELQRFLDTAFDLDAFKKFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Acetylation	ENPKSVHKSWDIFFR HCCCCCCCCCEEEEC	51.60	24062335
74	Succinylation	ENPKSVHKSWDIFFR HCCCCCCCCCEEEEC	51.60	23806337
74	Succinylation	ENPKSVHKSWDIFFR HCCCCCCCCCEEEEC	51.60	-
91	Phosphorylation	NAGAPPGTAYQSPLS CCCCCCCCCCCCCCC	28.15	27742792
93	Phosphorylation	GAPPGTAYQSPLSLS CCCCCCCCCCCCCCC	14.90	29472430
95	Phosphorylation	PPGTAYQSPLSLSRS CCCCCCCCCCCCCHH	18.35	27742792
98	Phosphorylation	TAYQSPLSLSRSSLA CCCCCCCCCCHHHHH	27.90	27742792
100	Phosphorylation	YQSPLSLSRSSLATM CCCCCCCCHHHHHHH	27.09	27742792
102	Phosphorylation	SPLSLSRSSLATMAH CCCCCCHHHHHHHHH	26.74	27742792
103	Phosphorylation	PLSLSRSSLATMAHA CCCCCHHHHHHHHHH	22.40	20495213
106	Phosphorylation	LSRSSLATMAHAQSL CCHHHHHHHHHHHHH	21.86	27742792
112	Phosphorylation	ATMAHAQSLVEAQPN HHHHHHHHHHHHCCC	34.86	27742792
160	Phosphorylation	LDADLDSSVPADIIS CCCCCCCCCCHHHHC	31.61	21082442
180	Phosphorylation	GFYGLHESDLDKVFH CCCCCCHHHHCCEEE	32.50	23737553
181 (in isoform 4)	Phosphorylation	-	56.77	21183079
185 (in isoform 3)	Phosphorylation	-	3.50	21183079
191 (in isoform 4)	Phosphorylation	-	20.12	21183079
195 (in isoform 3)	Phosphorylation	-	27.78	21183079
237	Acetylation	QCQWIRQKFETPGIM HHHHHHHHCCCCCHH	35.01	23201123
253	Phosphorylation	FTNEEKRTLLARLVR CCCHHHHHHHHHHHH	36.87	21454597
261	Phosphorylation	LLARLVRSTRFEEFL HHHHHHHHHCHHHHH	19.22	21454597
262	Phosphorylation	LARLVRSTRFEEFLQ HHHHHHHHCHHHHHH	28.90	21454597
276	Acetylation	QRKWSSEKRFGLEGC HHHCCCCCCCCCCCH	55.78	2373387
283	Glutathionylation	KRFGLEGCEVLIPAL CCCCCCCHHCHHHHH	2.09	24333276
283	S-nitrosylation	KRFGLEGCEVLIPAL CCCCCCCHHCHHHHH	2.09	21278135
283	S-nitrosocysteine	KRFGLEGCEVLIPAL CCCCCCCHHCHHHHH	2.09	-
331	S-nitrosylation	KELEQIFCQFDSKLE HHHHHHHHHHHHHHH	4.15	21278135
331	S-nitrosocysteine	KELEQIFCQFDSKLE HHHHHHHHHHHHHHH	4.15	-
395	S-nitrosocysteine	TKAEQFYCGDTEGKK CCCEEEECCCCCCCE	4.14	-
395	S-nitrosylation	TKAEQFYCGDTEGKK CCCEEEECCCCCCCE	4.14	21278135
401	Acetylation	YCGDTEGKKVMSILL ECCCCCCCEEEEEEE	35.64	23576753
402	Acetylation	CGDTEGKKVMSILLH CCCCCCCEEEEEEEE	54.77	2393387
457	Phosphorylation	TDPRMARSSPYPTDV CCHHHHCCCCCCCHH	26.57	29472430
458	Phosphorylation	DPRMARSSPYPTDVA CHHHHCCCCCCCHHH	23.93	21082442
460	Phosphorylation	RMARSSPYPTDVARV HHHCCCCCCCHHHHH	22.25	29472430
462	Phosphorylation	ARSSPYPTDVARVVN HCCCCCCCHHHHHHC	36.94	29472430
485	Phosphorylation	DDPEAVMYVCKVAAE CCHHHHHHHHHHHHH	8.97	20495213
487	S-nitrosocysteine	PEAVMYVCKVAAEWR HHHHHHHHHHHHHHH	1.29	-
487	S-nitrosylation	PEAVMYVCKVAAEWR HHHHHHHHHHHHHHH	1.29	21278135
507	S-nitrosocysteine	DVVVDLVCYRRNGHN HEEEEEEEEECCCCC	2.58	-
507	Glutathionylation	DVVVDLVCYRRNGHN HEEEEEEEEECCCCC	2.58	24333276
507	S-nitrosylation	DVVVDLVCYRRNGHN HEEEEEEEEECCCCC	2.58	21278135
534	Acetylation	YKQIRKQKPVLQKYA HHHHHHCCHHHHHHH	39.88	23201123
546	Phosphorylation	KYAELLVSQGVVNQP HHHHHHHHCCCCCCH	22.61	-
555	Phosphorylation	GVVNQPEYEEEISKY CCCCCHHHHHHHHHH	35.01	22871156
560	Phosphorylation	PEYEEEISKYDKICE HHHHHHHHHHHHHHH	28.57	22871156
561	Acetylation	EYEEEISKYDKICEE HHHHHHHHHHHHHHH	64.23	23236377
564	Succinylation	EEISKYDKICEEAFT HHHHHHHHHHHHHHH	46.28	23806337
564	Succinylation	EEISKYDKICEEAFT HHHHHHHHHHHHHHH	46.28	-
564	Acetylation	EEISKYDKICEEAFT HHHHHHHHHHHHHHH	46.28	23806337
566	S-nitrosylation	ISKYDKICEEAFTRS HHHHHHHHHHHHHCC	4.81	21278135
566	Glutathionylation	ISKYDKICEEAFTRS HHHHHHHHHHHHHCC	4.81	24333276
566	S-palmitoylation	ISKYDKICEEAFTRS HHHHHHHHHHHHHCC	4.81	28526873
566	S-nitrosocysteine	ISKYDKICEEAFTRS HHHHHHHHHHHHHCC	4.81	-
604	S-nitrosocysteine	GQPRSMTCPSTGLEE CCCCCEECCCCCCCC	1.55	-
604	S-nitrosylation	GQPRSMTCPSTGLEE CCCCCEECCCCCCCC	1.55	21278135
604	S-palmitoylation	GQPRSMTCPSTGLEE CCCCCEECCCCCCCC	1.55	28680068
619	Acetylation	DVLFHIGKVASSVPV CEEEEHHCCCCCCCC	33.74	22733758
622	Phosphorylation	FHIGKVASSVPVENF EEHHCCCCCCCCCCE	34.55	25777480
623	Phosphorylation	HIGKVASSVPVENFT EHHCCCCCCCCCCEE	22.24	25777480
630	Phosphorylation	SVPVENFTIHGGLSR CCCCCCEEECCHHHH	24.52	25777480
636	Phosphorylation	FTIHGGLSRILKTRR EEECCHHHHHHHHHH	22.13	22817900
641	Phosphorylation	GLSRILKTRRELVTN HHHHHHHHHHHHHHC	31.36	25777480
658	Phosphorylation	VDWALAEYMAFGSLL HHHHHHHHHHHHHHH	6.53	21659604
682	Phosphorylation	GQDVERGTFSHRHHV CCCCCCCCCCCCCCC	28.34	-
684	Phosphorylation	DVERGTFSHRHHVLH CCCCCCCCCCCCCCC	21.32	-
697	Acetylation	LHDQNVDKRTCIPMN CCCCCCCCCCEEEHH	45.37	23201123
852	Succinylation	QILLPFRKPLIVFTP HHHCCCCCCEEEECC	44.55	23806337
852	Acetylation	QILLPFRKPLIVFTP HHHCCCCCCEEEECC	44.55	23806337
870	Phosphorylation	LRHPEARTSFDEMLP HCCHHHHCCHHHCCC	40.57	22817900
871	Phosphorylation	RHPEARTSFDEMLPG CCHHHHCCHHHCCCC	25.75	19060867
897	Acetylation	PAAQDPHKVKRLLFC CCCCCHHHHHHHHEE	55.64	23864654
899	Acetylation	AQDPHKVKRLLFCTG CCCHHHHHHHHEECC	41.97	23864654
904	S-nitrosylation	KVKRLLFCTGKVYYD HHHHHHEECCCCHHH	5.04	21278135
904	S-nitrosocysteine	KVKRLLFCTGKVYYD HHHHHHEECCCCHHH	5.04	-
934	Phosphorylation	ITRIEQLSPFPFDLL HHHHHHHCCCCHHHH	24.96	20495213
943	Succinylation	FPFDLLLKEAQKYPN CCHHHHHHHHHHCCC	51.47	23954790
943	Acetylation	FPFDLLLKEAQKYPN CCHHHHHHHHHHCCC	51.47	23954790
947	Acetylation	LLLKEAQKYPNAELA HHHHHHHHCCCCCCC	70.49	23201123
956	S-nitrosylation	PNAELAWCQEEHKNQ CCCCCCCCHHHHCCC	2.80	21278135
956	S-nitrosocysteine	PNAELAWCQEEHKNQ CCCCCCCCHHHHCCC	2.80	-
961	Acetylation	AWCQEEHKNQGYYDY CCCHHHHCCCCCHHH	55.00	24062335
966	Phosphorylation	EHKNQGYYDYVKPRL HHCCCCCHHHCCHHH	13.97	25195567
970	Succinylation	QGYYDYVKPRLRTTI CCCHHHCCHHHCCCC	20.42	23806337
970	Acetylation	QGYYDYVKPRLRTTI CCCHHHCCHHHCCCC	20.42	24062335
970	Glutarylation	QGYYDYVKPRLRTTI CCCHHHCCHHHCCCC	20.42	24703693
999	Acetylation	AAPATGNKKTHLTEL CCCCCCCCCCHHHHH	61.46	23576753
999	Succinylation	AAPATGNKKTHLTEL CCCCCCCCCCHHHHH	61.46	26388266
999	Glutarylation	AAPATGNKKTHLTEL CCCCCCCCCCHHHHH	61.46	24703693
1000	Acetylation	APATGNKKTHLTELQ CCCCCCCCCHHHHHH	45.22	6269757
1020	Acetylation	AFDLDAFKKFS---- HHCHHHHHHCC----	55.41	2415343
1020	Succinylation	AFDLDAFKKFS---- HHCHHHHHHCC----	55.41	26388266
1020	Ubiquitination	AFDLDAFKKFS---- HHCHHHHHHCC----	55.41	-
1020 (in isoform 3)	Ubiquitination	-	55.41	22790023
1021	Acetylation	FDLDAFKKFS----- HCHHHHHHCC-----	44.37	2413417
1035 (in isoform 3)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ODO1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ODO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ODO1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ODO1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.