TAP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAP2_MOUSE
• UniProt AC: P36371
• Protein Name: Antigen peptide transporter 2
• Gene Name: Tap2
• Organism: Mus musculus (Mouse).
• Sequence Length: 702
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. The transmembrane segments seem to form a pore in the membrane.
• Protein Description: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity)..
• Protein Sequence: MALSYLRPWVSLLLADMALLGLLQGSLGNLLPQGLPGLWIEGTLRLGVLWGLLKVGELLGLVGTLLPLLCLATPLFFSLRALVGGTASTSVVRVASASWGWLLAGYGAVALSWAVWAVLSPAGVQEKEPGQENRTLMKRLLKLSRPDLPFLIAAFFFLVVAVWGETLIPRYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSFSAGCRGGSFLFTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVSHYKEALERCRQLWWRRDLEKDVYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEEVGQYVRNLVYMYGDMLSNVGAAEKVFSYLDRKPNLPQPGILAPPWLEGRVEFQDVSFSYPRRPEKPVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNPRVLILDEATSALDAQCEQALQNWRSQGDRTMLVIAHRLHTVQNADQVLVLKQGRLVEHDQLRDGQDVYAHLVQQRLEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Phosphorylation	ELLGLVGTLLPLLCL HHHHHHHHHHHHHHH	20.03	-
218	Phosphorylation	GSFLFTMSRINLRIR CCEEEEECHHHHHHH	27.27	-
244	Ubiquitination	LGFFQETKTGELNSR CCCCCCCCCCCCCCC	54.50	22790023
355	Ubiquitination	EQEVSHYKEALERCR HHHHHHHHHHHHHHH	30.96	22790023
449	Ubiquitination	VFSYLDRKPNLPQPG HHHHHCCCCCCCCCC	37.61	22790023
692	Phosphorylation	LRDGQDVYAHLVQQR CCCCHHHHHHHHHHH	9.15	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TAP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.