MBL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MBL2_MOUSE
• UniProt AC: P41317
• Protein Name: Mannose-binding protein C
• Gene Name: Mbl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 244
• Subcellular Localization: Secreted.
• Protein Description: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity)..
• Protein Sequence: MSIFTSFLLLCVVTVVYAETLTEGVQNSCPVVTCSSPGLNGFPGKDGRDGAKGEKGEPGQGLRGLQGPPGKVGPTGPPGNPGLKGAVGPKGDRGDRAEFDTSEIDSEIAALRSELRALRNWVLFSLSEKVGKKYFVSSVKKMSLDRVKALCSEFQGSVATPRNAEENSAIQKVAKDIAYLGITDVRVEGSFEDLTGNRVRYTNWNDGEPNNTGDGEDCVVILGNGKWNDVPCSDSFLAICEFSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Hydroxylation	SPGLNGFPGKDGRDG CCCCCCCCCCCCCCC	50.77	-
58	Hydroxylation	AKGEKGEPGQGLRGL CCCCCCCCCCCCCCC	49.42	-
69	Hydroxylation	LRGLQGPPGKVGPTG CCCCCCCCCCCCCCC	63.16	-
78	Hydroxylation	KVGPTGPPGNPGLKG CCCCCCCCCCCCCCC	57.44	-
81	Hydroxylation	PTGPPGNPGLKGAVG CCCCCCCCCCCCCCC	56.24	-
152	Phosphorylation	DRVKALCSEFQGSVA HHHHHHHHHHCCCCC	42.15	25168779
157	Phosphorylation	LCSEFQGSVATPRNA HHHHHCCCCCCCCCH	9.59	25168779
160	Phosphorylation	EFQGSVATPRNAEEN HHCCCCCCCCCHHHC	22.18	25168779
183	Phosphorylation	DIAYLGITDVRVEGS HHHHCCCCEEEEEEC	27.00	24719451
190	Phosphorylation	TDVRVEGSFEDLTGN CEEEEEECEECCCCC	16.38	30352176
210	N-linked_Glycosylation	NWNDGEPNNTGDGED CCCCCCCCCCCCCCC	55.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MBL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MBL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MBL2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MBL2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.