RAB43_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB43_MOUSE
• UniProt AC: Q8CG50
• Protein Name: Ras-related protein Rab-43
• Gene Name: Rab43
• Organism: Mus musculus (Mouse).
• Sequence Length: 210
• Subcellular Localization: Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus . Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor . Golgi apparatus, trans-Golgi network . Recruited to phagosom
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium..
• Protein Sequence: MAGPGPGDQDEHYDFLFKLVLVGDASVGKTCVVQRFKTGAFSARQGSTIGVDFTMKTLEIQGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDISKRSTFLSVPHWIEDVRKYAGSNIVQLLIGNKSDLADFREVPLAEAQSLAEHYDILCAIETSAKDSSNVEEAFTRVATELIMRHGGPMFSEKNTDHIQLDSKDIAESWGCGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	AFSARQGSTIGVDFT CCCCCCCCEEEEEEE	14.44	19144319
80	Phosphorylation	AGQERFRTITQSYYR CCHHHHHHHHHHHHH	26.18	19144319
82	Phosphorylation	QERFRTITQSYYRSA HHHHHHHHHHHHHCC	15.73	21183079
88	Phosphorylation	ITQSYYRSANGAILA HHHHHHHCCCCCEEE	15.23	26239621
96	Phosphorylation	ANGAILAYDISKRST CCCCEEEEECCCCCC	15.46	28059163
99	Phosphorylation	AILAYDISKRSTFLS CEEEEECCCCCCCCC	21.08	28059163
117	Phosphorylation	WIEDVRKYAGSNIVQ HHHHHHHHCCCCHHH	12.96	21659604
120	Phosphorylation	DVRKYAGSNIVQLLI HHHHHCCCCHHHHHH	18.40	21659604
130	Ubiquitination	VQLLIGNKSDLADFR HHHHHCCHHHCCCCC	39.88	-
188	Phosphorylation	RHGGPMFSEKNTDHI HHCCCCCCCCCCCCE	41.21	-
208	Geranylgeranylation	DIAESWGCGC----- HHHHHCCCCC-----	4.01	-
210	Methylation	AESWGCGC------- HHHCCCCC-------	6.15	-
210	Geranylgeranylation	AESWGCGC------- HHHCCCCC-------	6.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
80	T	Phosphorylation	Kinase	LRRK2	Q5S006	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB43_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB43_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB43_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-80, AND MASSSPECTROMETRY.
PubMed: 19144319