MCAT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCAT_MOUSE
• UniProt AC: Q9Z2Z6
• Protein Name: Mitochondrial carnitine/acylcarnitine carrier protein
• Gene Name: Slc25a20
• Organism: Mus musculus (Mouse).
• Sequence Length: 301
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway..
• Protein Sequence: MADEPKPISPFKNLLAGGFGGMCLVFVGHPLDTVKVRLQTQPPSLSGQPPMYSGTLDCFRKTLMREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKSPEDELSYPQLFTAGMLSGVFTTGIMTPGERIKCLLQIQASSGENKYSGTLDCAKKLYQEFGIRGFYKGTVLTLMRDVPASGMYFMTYEWLKNLFTPEGKSVSDLSVPRILVAGGFAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIREEGVTSLYKGFNAVMIRAFPANAACFLGFEIAMKFLNWIAPNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADEPKPIS ------CCCCCCCCC	29.85	-
6	Acetylation	--MADEPKPISPFKN --CCCCCCCCCHHHH	53.59	23201123
9	Phosphorylation	ADEPKPISPFKNLLA CCCCCCCCHHHHHHC	32.58	20469934
58	S-nitrosocysteine	MYSGTLDCFRKTLMR CCCCHHHHHHHHHHH	3.90	-
58	S-palmitoylation	MYSGTLDCFRKTLMR CCCCHHHHHHHHHHH	3.90	28526873
58	S-nitrosylation	MYSGTLDCFRKTLMR CCCCHHHHHHHHHHH	3.90	21278135
136	S-nitrosylation	TPGERIKCLLQIQAS CCCHHEEEEEEEEEC	4.22	21278135
136	S-nitrosocysteine	TPGERIKCLLQIQAS CCCHHEEEEEEEEEC	4.22	-
143	Phosphorylation	CLLQIQASSGENKYS EEEEEEECCCCCCCC	23.62	25521595
144	Phosphorylation	LLQIQASSGENKYSG EEEEEECCCCCCCCC	53.82	25521595
148	Acetylation	QASSGENKYSGTLDC EECCCCCCCCCHHHH	36.17	23576753
155	S-nitrosocysteine	KYSGTLDCAKKLYQE CCCCHHHHHHHHHHH	7.23	-
155	S-nitrosylation	KYSGTLDCAKKLYQE CCCCHHHHHHHHHHH	7.23	21278135
157	Acetylation	SGTLDCAKKLYQEFG CCHHHHHHHHHHHHC	50.03	23576753
158	Acetylation	GTLDCAKKLYQEFGI CHHHHHHHHHHHHCC	33.62	23576753
170	Acetylation	FGIRGFYKGTVLTLM HCCCCEEECCEEEEE	45.93	23576753
170	Succinylation	FGIRGFYKGTVLTLM HCCCCEEECCEEEEE	45.93	-
170	Succinylation	FGIRGFYKGTVLTLM HCCCCEEECCEEEEE	45.93	23806337
202	Ubiquitination	NLFTPEGKSVSDLSV HHCCCCCCCHHHCCC	46.12	-
244	Acetylation	FQTAPPGKYPNGFRD HCCCCCCCCCCCHHH	64.41	23864654
283	S-nitrosocysteine	AFPANAACFLGFEIA ECCCCHHHHHHHHHH	2.41	-
283	S-nitrosylation	AFPANAACFLGFEIA ECCCCHHHHHHHHHH	2.41	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCAT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCAT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCAT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MCAT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148 AND LYS-244, AND MASSSPECTROMETRY.
PubMed: 16916647