UBA1Y_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBA1Y_MOUSE
• UniProt AC: P31254
• Protein Name: Ubiquitin-like modifier-activating enzyme 1 Y
• Gene Name: Uba1y
• Organism: Mus musculus (Mouse).
• Sequence Length: 1058
• Protein Description: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia..
• Protein Sequence: MSSSVLSKKRKVSGPDSSLDSSWSPTYSVMFGVPPGPTNEMSKNKEMDIDESLYSRQLYVLGHEAMKHLQASSVLISGLQGLGVEIAKNIILGGVKAVTLHDQGIAQWADLSSQFCLREEDIGKNRAEISQPRLAELNSYVPVFAYTGPLIEEFLSGFQVVVLTNTPLEYQLQVGEFCHSHGIKLVVADTRGLVGQLFCDFGEEMILTDSNGEQPLSAMVSMITKENPGIVTCLEDSRHGFESGDFISFTEVQGMSELNGIGPIEIKVLGPYTFSICDTSSFSEYIRGGIVSQVKVPRKINFKPLLASLAEPEFVVTDFAKCCHPAQLHIGFQALHQFCTQHSRPPRPHNEEDAEELVTLAQSVNAQALPAVQQDCLDIDLIRKLAYVAAGDLAPMNAFFGGLAAQEVMKACSGKFMPIRQWLYFDALECLPEHRVAFMEDKCLPHQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEDGEITVTDMDTIEKSNLNRQFLFRPWDITKLKSETAAAAVRDINPHIRIFSHQNRVGPETEHVYDDDFFQKLDGVANALDNVDARLYVDRRCVYYRKPLLESGTLGTKGNVQVVVPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTVQWARDEFEGLFKQSAENVNQYLTDPKFMERTLQLAGTQPLEVLEAIHCSLVLQRPQTWADCVTWAYQHWHTQYSHNIQQLLHNFPPAQLTSSGALFWSGPKRCPHPLTFDINNPLHLDYVMAAANLFAQTYGLGGSQDCAVVAKLLQSLPVPKFAPKSGIRIHVSEQELQSTSATTIDDSHLEELKTALPTPDKLLGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYGISPADRHKSKLIAGKIIPAIATTTSAIVGLVCLELYKVVQGHQQLESYKNSFINLALPLFSFSAPLAPECHQYYDQEWTLWDRFDVQGLQPSGEEMTLKQFLDYFKTEHKLEVIMLSQGVSMLYSVFMPASKLKERLDQPMTEIVSCVSKQKLGHHVKSLVFELCCNSDSGDDIEVPYVRYIIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	LSKKRKVSGPDSSLD HCCCCCCCCCCCCCC	47.87	25293948
17	Phosphorylation	RKVSGPDSSLDSSWS CCCCCCCCCCCCCCC	35.61	25293948
18	Phosphorylation	KVSGPDSSLDSSWSP CCCCCCCCCCCCCCC	43.51	25293948
21	Phosphorylation	GPDSSLDSSWSPTYS CCCCCCCCCCCCCEE	38.71	21183079
22	Phosphorylation	PDSSLDSSWSPTYSV CCCCCCCCCCCCEEE	31.10	21183079
24	Phosphorylation	SSLDSSWSPTYSVMF CCCCCCCCCCEEEEC	14.87	21183079
26	Phosphorylation	LDSSWSPTYSVMFGV CCCCCCCCEEEECCC	23.94	25293948
27	Phosphorylation	DSSWSPTYSVMFGVP CCCCCCCEEEECCCC	11.58	25293948
28	Phosphorylation	SSWSPTYSVMFGVPP CCCCCCEEEECCCCC	15.02	21183079
54	Phosphorylation	MDIDESLYSRQLYVL CCCCHHHHHHHHHHH	15.87	22817900
59	Phosphorylation	SLYSRQLYVLGHEAM HHHHHHHHHHHHHHH	5.81	25367039
88	Acetylation	GLGVEIAKNIILGGV HCCHHHHHHHEECCE	55.10	22826441
130	Phosphorylation	GKNRAEISQPRLAEL CCCHHHHCCHHHHHH	26.15	26745281
184	Ubiquitination	FCHSHGIKLVVADTR HHHHCCCEEEEECCC	39.56	-
387	Phosphorylation	DLIRKLAYVAAGDLA HHHHHHHHHHHCCCC	10.89	-
469	Acetylation	QEKLGKQKYFLVGAG HHHHCCCCEEEECCC	41.26	22826441
592	Ubiquitination	RRCVYYRKPLLESGT CCCEEEECCCCCCCC	24.72	-
599	Phosphorylation	KPLLESGTLGTKGNV CCCCCCCCCCCCCCE	31.15	25338131
627	Phosphorylation	SQDPPEKSIPICTLK CCCCCCCCCCEEEEC	31.75	22324799
631	Glutathionylation	PEKSIPICTLKNFPN CCCCCCEEEECCCCC	2.82	24333276
634	Ubiquitination	SIPICTLKNFPNAIE CCCEEEECCCCCHHH	38.09	-
809	Phosphorylation	SGIRIHVSEQELQST CCEEEEECHHHHHCC	21.28	25293948
851	Ubiquitination	MYPIDFEKDDDSNFH EEECCCCCCCCCCCC	67.46	-
876	Phosphorylation	RAENYGISPADRHKS CHHHCCCCHHHHHHH	15.07	-
883	Phosphorylation	SPADRHKSKLIAGKI CHHHHHHHHHHHCCH	26.94	-
889	Ubiquitination	KSKLIAGKIIPAIAT HHHHHHCCHHHHHHH	28.57	-
896	Phosphorylation	KIIPAIATTTSAIVG CHHHHHHHHHHHHHH	25.21	26239621
897	Phosphorylation	IIPAIATTTSAIVGL HHHHHHHHHHHHHHH	15.10	26239621
898	Phosphorylation	IPAIATTTSAIVGLV HHHHHHHHHHHHHHH	16.29	26239621
899	Phosphorylation	PAIATTTSAIVGLVC HHHHHHHHHHHHHHH	17.57	26239621
981	Phosphorylation	QFLDYFKTEHKLEVI HHHHHHHHHCHHHEE	33.16	19854140
991	Phosphorylation	KLEVIMLSQGVSMLY HHHEEECCCCHHHHH	13.91	19854140
999	Phosphorylation	QGVSMLYSVFMPASK CCHHHHHHHHCCHHH	12.62	28059163
1005	Phosphorylation	YSVFMPASKLKERLD HHHHCCHHHHHHHCC	32.42	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBA1Y_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBA1Y_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBA1Y_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBA1Y_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.