dbPTM

ICMT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ICMT_MOUSE
UniProt AC	Q9EQK7
Protein Name	Protein-S-isoprenylcysteine O-methyltransferase
Gene Name	Icmt
Organism	Mus musculus (Mouse).
Sequence Length	283
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein.
Protein Description	Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues..
Protein Sequence	MAAARRGSAGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGVLLSFSQSSWNHFGWYVCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITWLSATGLLMVVFGECLRKAAMFTAGSNFNHVVQSEKSDTHTLVTSGVYAWCRHPSYVGWFYWSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLIHFFGEEYLDYKKRVPTGLPFIKGVKVEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
193	Phosphorylation	HVVQSEKSDTHTLVT HHHCCCCCCCCEEEE	43.63	22871156
195	Phosphorylation	VQSEKSDTHTLVTSG HCCCCCCCCEEEECC	24.69	22871156
197	Phosphorylation	SEKSDTHTLVTSGVY CCCCCCCEEEECCCC	25.64	22871156
201	Phosphorylation	DTHTLVTSGVYAWCR CCCEEEECCCCHHHC	20.84	22871156
204	Phosphorylation	TLVTSGVYAWCRHPS EEEECCCCHHHCCHH	9.63	22871156
271	Phosphorylation	DYKKRVPTGLPFIKG CHHHCCCCCCCCCCC	48.79	20139300
277	Ubiquitination	PTGLPFIKGVKVEL- CCCCCCCCCEEECC-	59.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ICMT_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ICMT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ICMT_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ICMT_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ICMT_MOUSE

Related Literatures of Post-Translational Modification