FIBB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FIBB_MOUSE
• UniProt AC: Q8K0E8
• Protein Name: Fibrinogen beta chain
• Gene Name: Fgb
• Organism: Mus musculus (Mouse).
• Sequence Length: 481
• Subcellular Localization: Secreted .
• Protein Description: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways..
• Protein Sequence: MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQERPIKSSIAELNNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVINEYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEASKYQVSVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPFFPQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Ubiquitination	HRPVDRRKEEPPSLR CCCCCCCCCCCCCCC	68.29	-
237	Ubiquitination	ECEEIIRKGGETSEM HHHHHHHCCCCCCEE	61.94	-
254	Ubiquitination	IQPDTSIKPYRVYCD ECCCCCCCCEEEEEE	35.45	-
263	Ubiquitination	YRVYCDMKTENGGWT EEEEEEEECCCCCEE	39.16	-
303	Acetylation	IATNEDAKKYCGLPG CCCCHHHHHHCCCCC	57.51	7619175
303	Ubiquitination	IATNEDAKKYCGLPG CCCCHHHHHHCCCCC	57.51	-
303	Succinylation	IATNEDAKKYCGLPG CCCCHHHHHHCCCCC	57.51	23954790
343	Ubiquitination	DWKGDKVKAHYGGFT CCCCCEEEEEECCEE	34.88	-
364	Ubiquitination	KYQVSVNKYKGTAGN CEEEECEECCCCHHH	46.30	-
384	N-linked_Glycosylation	ASQLVGENRTMTIHN HHHHHCCCCEEEEEC	38.50	-
386	Phosphorylation	QLVGENRTMTIHNGM HHHCCCCEEEEECCE	30.19	25293948
388	Phosphorylation	VGENRTMTIHNGMFF HCCCCEEEEECCEEE	20.62	25293948
396	Phosphorylation	IHNGMFFSTYDRDND EECCEEEECEECCCC	18.13	25293948
397	Phosphorylation	HNGMFFSTYDRDNDG ECCEEEECEECCCCC	25.04	25293948
398	Phosphorylation	NGMFFSTYDRDNDGW CCEEEECEECCCCCE	14.05	25293948
416	Ubiquitination	DPRKQCSKEDGGGWW CCCCCCCCCCCCCCC	68.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FIBB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FIBB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FIBB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FIBB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.