PBIP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PBIP1_MOUSE
• UniProt AC: Q3TVI8
• Protein Name: Pre-B-cell leukemia transcription factor-interacting protein 1
• Gene Name: Pbxip1
• Organism: Mus musculus (Mouse).
• Sequence Length: 727
• Subcellular Localization: Cytoplasm, cytoskeleton . Nucleus . Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.
• Protein Description: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity)..
• Protein Sequence: MASCPDSDNSWVLAGSENLPVETLGPEPRMDPESEGASQALRDSSKADGKELAGTLDGEEKLFQTESSQRETAVLTESAAKGTLGADGHGTEAPGDTVVQEDSQETPVATSLGPDTQDLESEIHPQNLPSSPRAVWKEHRCSSSDDDTDVDVEGLRRRRGREPSSSQPVVPVDVEDQAKGEGIGGELGISLNMCFLGALVLLGLGILLFSGTLLEPETGPMEEAELQVFPETGPETELVETLGNRQDEIEHLQASSVPPDSVPSLQSMGFLLDKLAKENQDIRLLQAQLQAQKEELQSLLHQPKGLEEENARLREALQQGKTSHQALESELQQLRARLQGLEANCVRGVDGVCLNWGGDPQDGKATKEQGHKGQEPDPSLLEQHKQLEAEAKALRQELQRQWQLLGSVHWDLQRGLRDAGRGAPAHPGLAELGHMLAQTLQDLENQGINTGRSPNDSEAWHQKKPHTQSPREWGGKEKWRGGQRDQKAEHWKPRKEESGQERQRSWRDEGREHTGRWREDRLRADESGSRKDSKRQDPKVHPRKDGNSHSVERQKHSWGKDNSPDALSSWEELLRRKYRPPQGCSGVADCARQEGLALFGVELAPVRQQELASVLREYLSRLPWAGQLTKQLPLSPAYFGEDGIFRHDRLRFRDFVDALEDSLEEVALKQTGDDDEVDDFEDFVFGHFFGDKALKKRSRKKEKHSWNPRVVGPREEHSRHPHHYHQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
121	Phosphorylation	PDTQDLESEIHPQNL CCCHHHHHHCCCCCC	49.50	22802335
130	Phosphorylation	IHPQNLPSSPRAVWK CCCCCCCCCCCHHHH	57.02	25338131
131	Phosphorylation	HPQNLPSSPRAVWKE CCCCCCCCCCHHHHH	19.23	22802335
142	Phosphorylation	VWKEHRCSSSDDDTD HHHHCCCCCCCCCCC	32.60	27087446
143	Phosphorylation	WKEHRCSSSDDDTDV HHHCCCCCCCCCCCC	41.22	27087446
144	Phosphorylation	KEHRCSSSDDDTDVD HHCCCCCCCCCCCCC	28.85	27087446
148	Phosphorylation	CSSSDDDTDVDVEGL CCCCCCCCCCCHHHH	44.94	24899341
164	Phosphorylation	RRRGREPSSSQPVVP HHCCCCCCCCCCCEE	37.56	25521595
165	Phosphorylation	RRGREPSSSQPVVPV HCCCCCCCCCCCEEC	43.65	25521595
166	Phosphorylation	RGREPSSSQPVVPVD CCCCCCCCCCCEECC	42.72	25521595
322	Phosphorylation	EALQQGKTSHQALES HHHHHCCHHHHHHHH	37.96	28464351
323	Phosphorylation	ALQQGKTSHQALESE HHHHCCHHHHHHHHH	19.65	28464351
329	Phosphorylation	TSHQALESELQQLRA HHHHHHHHHHHHHHH	44.44	22210690
367	Acetylation	PQDGKATKEQGHKGQ CCCCCCCHHCCCCCC	53.55	8277157
372	Acetylation	ATKEQGHKGQEPDPS CCHHCCCCCCCCCHH	69.94	8277167
385	Acetylation	PSLLEQHKQLEAEAK HHHHHHHHHHHHHHH	57.16	8277177
453	O-linked_Glycosylation	QGINTGRSPNDSEAW CCCCCCCCCCCHHHH	29.42	30059200
550	Phosphorylation	RKDGNSHSVERQKHS CCCCCCCCHHHHHCC	26.03	23375375
557	Phosphorylation	SVERQKHSWGKDNSP CHHHHHCCCCCCCCC	44.55	24719451
563	Phosphorylation	HSWGKDNSPDALSSW CCCCCCCCCCHHHHH	34.00	-
568	Phosphorylation	DNSPDALSSWEELLR CCCCCHHHHHHHHHH	34.82	27566939
569	Phosphorylation	NSPDALSSWEELLRR CCCCHHHHHHHHHHH	39.08	27566939

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PBIP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PBIP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PBIP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PBIP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142; SER-143 ANDSER-144, AND MASS SPECTROMETRY.
PubMed: 17242355