AVIL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AVIL_MOUSE
• UniProt AC: O88398
• Protein Name: Advillin
• Gene Name: Avil
• Organism: Mus musculus (Mouse).
• Sequence Length: 819
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection. Cell projection, axon.
• Protein Description: Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis..
• Protein Sequence: MSLSSAFRAVSNDPRIITWRIEKMELALVPLSAHGNFYEGDCYIVLSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIQATEVEMSWDSFNRGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPGLMTVLQDTLGRRSMIKPAVSDEIMDQQQKSSIMLYHVSDTAGQLSVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTTGLGKIFSTGKIAKIFQDKFDVSLLHTKPEVAAQERMVDDGKGQVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPHYILYIWQGRHASRDELAASAYRAVEVDQQFDGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNEEPDPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELVDLLCDGNADTVAEGQEPPEFWDLLGGKTAYANDKRLQQETLDVQVRLFECSNKTGRFLVTEVTDFTQEDLSPGDVMLLDTWDQVFLWIGAEANATEKKGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITADMKNATLYLNPSDGEPKYYPVEVLLKGQNQELPEDVDPAKKENYLSEQDFVSVFGITRGQFTALPGWKQLQLKKERGLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	YTTQLDDYLGGSPVQ EEECHHHHCCCCCCC	13.60	22817900
221	Phosphorylation	AASPGLMTVLQDTLG HCCCCHHHHHHHHHC	24.09	28285833
226	Phosphorylation	LMTVLQDTLGRRSMI HHHHHHHHHCCCCCC	20.39	28285833
360	Phosphorylation	TGLGKIFSTGKIAKI CCCCHHHCCCHHHHH	39.46	24719451
458	Phosphorylation	DELAASAYRAVEVDQ HHHHHHHHHHEECHH	9.16	22817900
622	Phosphorylation	QVRLFECSNKTGRFL EEEEEECCCCCCCEE	33.88	22871156
721	Phosphorylation	HIWSEGKSYEQLKNE HHHCCCCCHHHHHHH	44.77	29895711
739	Phosphorylation	ATAIVRITADMKNAT CEEEEEEEECCCCCE	13.17	29895711
746	Phosphorylation	TADMKNATLYLNPSD EECCCCCEEEECCCC	25.90	29895711
748	Phosphorylation	DMKNATLYLNPSDGE CCCCCEEEECCCCCC	10.48	29895711
758	Phosphorylation	PSDGEPKYYPVEVLL CCCCCCCEEEEEEEE	24.58	22817900
759	Phosphorylation	SDGEPKYYPVEVLLK CCCCCCEEEEEEEEC	13.61	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AVIL_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AVIL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AVIL_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AVIL_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-85; TYR-748 AND TYR-758,AND MASS SPECTROMETRY.
PubMed: 17947660