AL1A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AL1A1_MOUSE
• UniProt AC: P24549
• Protein Name: Retinal dehydrogenase 1 {ECO:0000305}
• Gene Name: Aldh1a1 {ECO:0000312|MGI:MGI:1353450}
• Organism: Mus musculus (Mouse).
• Sequence Length: 501
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity)..
• Protein Sequence: MSSPAQPAVPAPLADLKIQHTKIFINNEWHNSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATMEALNGGKVFANAYLSDLGGCIKALKYCAGWADKIHGQTIPSDGDIFTYTRREPIGVCGQIIPWNFPMLMFIWKIGPALSCGNTVVVKPAEQTPLTALHLASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVKRSVERAKKYVLGNPLTPGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSVDDVIKRANNTTYGLAAGLFTKDLDKAITVSSALQAGVVWVNCYMMLSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSPAQPAV ------CCCCCCCCC	45.06	-
2	Phosphorylation	------MSSPAQPAV ------CCCCCCCCC	45.06	26643407
3	Phosphorylation	-----MSSPAQPAVP -----CCCCCCCCCC	23.98	26643407
17	Ubiquitination	PAPLADLKIQHTKIF CCCHHHCEEEEEEEE	40.65	-
17	Malonylation	PAPLADLKIQHTKIF CCCHHHCEEEEEEEE	40.65	26320211
17	Acetylation	PAPLADLKIQHTKIF CCCHHHCEEEEEEEE	40.65	23954790
22	Ubiquitination	DLKIQHTKIFINNEW HCEEEEEEEEECCCE	33.23	-
22	Malonylation	DLKIQHTKIFINNEW HCEEEEEEEEECCCE	33.23	25418362
36	Acetylation	WHNSVSGKKFPVLNP EECCCCCCCCCCCCC	43.67	7618863
36	Ubiquitination	WHNSVSGKKFPVLNP EECCCCCCCCCCCCC	43.67	-
36	Malonylation	WHNSVSGKKFPVLNP EECCCCCCCCCCCCC	43.67	26320211
37	Malonylation	HNSVSGKKFPVLNPA ECCCCCCCCCCCCCC	59.43	26320211
50	S-palmitoylation	PATEEVICHVEEGDK CCCCEEEEECCCCCH	3.39	28526873
57	Acetylation	CHVEEGDKADVDKAV EECCCCCHHHHHHHH	58.29	-
57	Malonylation	CHVEEGDKADVDKAV EECCCCCHHHHHHHH	58.29	26073543
62	Acetylation	GDKADVDKAVKAARQ CCHHHHHHHHHHHHH	55.73	-
62	Ubiquitination	GDKADVDKAVKAARQ CCHHHHHHHHHHHHH	55.73	22790023
79	Phosphorylation	QIGSPWRTMDASERG HCCCCCCCCCHHHHH	18.61	-
91	Ubiquitination	ERGRLLNKLADLMER HHHHHHHHHHHHHHH	45.05	27667366
91	Acetylation	ERGRLLNKLADLMER HHHHHHHHHHHHHHH	45.05	22646199
91	Malonylation	ERGRLLNKLADLMER HHHHHHHHHHHHHHH	45.05	26073543
121	Phosphorylation	VFANAYLSDLGGCIK EEHHHHHHHHHHHHH	20.36	18840083
126	S-palmitoylation	YLSDLGGCIKALKYC HHHHHHHHHHHHHHH	2.47	28526873
128	Acetylation	SDLGGCIKALKYCAG HHHHHHHHHHHHHHC	52.31	-
128	Ubiquitination	SDLGGCIKALKYCAG HHHHHHHHHHHHHHC	52.31	22790023
131	Ubiquitination	GGCIKALKYCAGWAD HHHHHHHHHHHCCHH	43.05	22790023
133	S-palmitoylation	CIKALKYCAGWADKI HHHHHHHHHCCHHHH	2.42	28526873
139	Ubiquitination	YCAGWADKIHGQTIP HHHCCHHHHCCEECC	28.93	22790023
186	S-palmitoylation	KIGPALSCGNTVVVK HHCCCCCCCCEEEEC	5.18	28526873
193	Ubiquitination	CGNTVVVKPAEQTPL CCCEEEECCCHHCCC	27.22	22790023
207	Phosphorylation	LTALHLASLIKEAGF CHHHHHHHHHHHHCC	36.67	20469934
210	Acetylation	LHLASLIKEAGFPPG HHHHHHHHHHCCCCC	46.97	23954790
245	Phosphorylation	DVDKVAFTGSTQVGK CCCEEEEECCHHHHH	22.08	29472430
247	Phosphorylation	DKVAFTGSTQVGKLI CEEEEECCHHHHHHH	16.77	30352176
248	Phosphorylation	KVAFTGSTQVGKLIK EEEEECCHHHHHHHH	28.72	29472430
252	Malonylation	TGSTQVGKLIKEAAG ECCHHHHHHHHHHCC	48.45	26320211
252	Ubiquitination	TGSTQVGKLIKEAAG ECCHHHHHHHHHHCC	48.45	-
252	Acetylation	TGSTQVGKLIKEAAG ECCHHHHHHHHHHCC	48.45	23954790
255	Malonylation	TQVGKLIKEAAGKSN HHHHHHHHHHCCCCC	52.30	26320211
255	Ubiquitination	TQVGKLIKEAAGKSN HHHHHHHHHHCCCCC	52.30	22790023
260	Malonylation	LIKEAAGKSNLKRVT HHHHHCCCCCCCEEE	31.29	26320211
267	Phosphorylation	KSNLKRVTLELGGKS CCCCCEEEEEECCCC	20.67	22324799
321	Ubiquitination	SVYDEFVKRSVERAK HHHHHHHHHHHHHHH	44.25	-
321	Succinylation	SVYDEFVKRSVERAK HHHHHHHHHHHHHHH	44.25	23954790
321	Acetylation	SVYDEFVKRSVERAK HHHHHHHHHHHHHHH	44.25	23954790
329	Malonylation	RSVERAKKYVLGNPL HHHHHHHHHHCCCCC	39.34	26320211
329	Ubiquitination	RSVERAKKYVLGNPL HHHHHHHHHHCCCCC	39.34	27667366
337	Phosphorylation	YVLGNPLTPGINQGP HHCCCCCCCCCCCCC	22.26	21743459
348	Ubiquitination	NQGPQIDKEQHDKIL CCCCCCCHHHHHHHH	61.99	22790023
348	Acetylation	NQGPQIDKEQHDKIL CCCCCCCHHHHHHHH	61.99	23201123
353	Acetylation	IDKEQHDKILDLIES CCHHHHHHHHHHHHH	42.94	23954790
353	Ubiquitination	IDKEQHDKILDLIES CCHHHHHHHHHHHHH	42.94	22790023
360	Phosphorylation	KILDLIESGKKEGAK HHHHHHHHCCCCCCE	49.25	20469934
362	Acetylation	LDLIESGKKEGAKLE HHHHHHCCCCCCEEE	57.86	23806337
362	Ubiquitination	LDLIESGKKEGAKLE HHHHHHCCCCCCEEE	57.86	27667366
362	Malonylation	LDLIESGKKEGAKLE HHHHHHCCCCCCEEE	57.86	26320211
362	Succinylation	LDLIESGKKEGAKLE HHHHHHCCCCCCEEE	57.86	-
363	Ubiquitination	DLIESGKKEGAKLEC HHHHHCCCCCCEEEE	65.98	22790023
363	Malonylation	DLIESGKKEGAKLEC HHHHHCCCCCCEEEE	65.98	25418362
367	Acetylation	SGKKEGAKLECGGGR HCCCCCCEEEECCCC	56.53	-
367	Malonylation	SGKKEGAKLECGGGR HCCCCCCEEEECCCC	56.53	26320211
378	Acetylation	GGGRWGNKGFFVQPT CCCCCCCCCCEECCE	53.83	7872783
378	Ubiquitination	GGGRWGNKGFFVQPT CCCCCCCCCCEECCE	53.83	-
378	Malonylation	GGGRWGNKGFFVQPT CCCCCCCCCCEECCE	53.83	26073543
388	Phosphorylation	FVQPTVFSNVTDEMR EECCEEECCCCHHHH	26.50	23984901
391	Phosphorylation	PTVFSNVTDEMRIAK CEEECCCCHHHHHHH	30.41	23984901
398	Malonylation	TDEMRIAKEEIFGPV CHHHHHHHHHHHCHH	54.21	26320211
398	Ubiquitination	TDEMRIAKEEIFGPV CHHHHHHHHHHHCHH	54.21	22790023
410	Ubiquitination	GPVQQIMKFKSVDDV CHHHHHHHCCCHHHH	51.79	22790023
410	Acetylation	GPVQQIMKFKSVDDV CHHHHHHHCCCHHHH	51.79	22733758
412	Malonylation	VQQIMKFKSVDDVIK HHHHHHCCCHHHHHH	44.01	26320211
412	Ubiquitination	VQQIMKFKSVDDVIK HHHHHHCCCHHHHHH	44.01	27667366
412	Succinylation	VQQIMKFKSVDDVIK HHHHHHCCCHHHHHH	44.01	-
412	Acetylation	VQQIMKFKSVDDVIK HHHHHHCCCHHHHHH	44.01	23864654
413	Phosphorylation	QQIMKFKSVDDVIKR HHHHHCCCHHHHHHH	33.63	51459323
419	Malonylation	KSVDDVIKRANNTTY CCHHHHHHHHHCCCC	45.35	26320211
419	Ubiquitination	KSVDDVIKRANNTTY CCHHHHHHHHHCCCC	45.35	27667366
419	Acetylation	KSVDDVIKRANNTTY CCHHHHHHHHHCCCC	45.35	23864654
425	Phosphorylation	IKRANNTTYGLAAGL HHHHHCCCCCEEEEC	20.09	51459315
426	Phosphorylation	KRANNTTYGLAAGLF HHHHCCCCCEEEECC	14.22	17242355
435	Acetylation	LAAGLFTKDLDKAIT EEEECCCCCHHHCCC	49.30	23954790
435	Ubiquitination	LAAGLFTKDLDKAIT EEEECCCCCHHHCCC	49.30	22790023
484	Phosphorylation	ELGEHGLYEYTELKT CCCCCCCEEHHHHHH	16.10	25521595
486	Phosphorylation	GEHGLYEYTELKTVA CCCCCEEHHHHHHHH	7.61	8236719
490	Acetylation	LYEYTELKTVAMKIS CEEHHHHHHHHHHHH	34.42	23954790
490	Succinylation	LYEYTELKTVAMKIS CEEHHHHHHHHHHHH	34.42	23954790
490	Ubiquitination	LYEYTELKTVAMKIS CEEHHHHHHHHHHHH	34.42	-
495	Acetylation	ELKTVAMKISQKNS- HHHHHHHHHHHCCC-	29.48	-
495	Malonylation	ELKTVAMKISQKNS- HHHHHHHHHHHCCC-	29.48	26320211
495	Ubiquitination	ELKTVAMKISQKNS- HHHHHHHHHHHCCC-	29.48	27667366
499	Ubiquitination	VAMKISQKNS----- HHHHHHHCCC-----	52.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AL1A1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AL1A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AL1A1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AL1A1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.