CBLN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBLN1_MOUSE
• UniProt AC: Q9R171
• Protein Name: Cerebellin-1
• Gene Name: Cbln1
• Organism: Mus musculus (Mouse).
• Sequence Length: 193
• Subcellular Localization: Secreted. Cell junction, synapse, postsynaptic cell membrane. Interaction with CBLN3 may cause partial retention in the endoplasmic reticulum.
• Protein Description: Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. [PubMed: 16234806 Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components]
• Protein Sequence: MLGVVELLLLGTAWLAGPARGQNETEPIVLEGKCLVVCDSNPTSDPTGTALGISVRSGSAKVAFSAIRSTNHEPSEMSNRTMIIYFDQVLVNIGNNFDSERSTFIAPRKGIYSFNFHVVKVYNRQTIQVSLMLNGWPVISAFAGDQDVTREAASNGVLIQMEKGDRAYLKLERGNLMGGWKYSTFSGFLVFPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	N-linked_Glycosylation	AGPARGQNETEPIVL HCCCCCCCCCCCEEE	62.07	29782851
79	N-linked_Glycosylation	HEPSEMSNRTMIIYF CCCCCCCCCEEEEEE	41.97	29782851
182	Phosphorylation	NLMGGWKYSTFSGFL CCCCCEEEECCCEEE	13.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBLN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBLN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBLN1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CBLN1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Cbln1 is essential for synaptic integrity and plasticity in thecerebellum.";
Hirai H., Pang Z., Bao D., Miyazaki T., Li L., Miura E., Parris J.,Rong Y., Watanabe M., Yuzaki M., Morgan J.I.;
Nat. Neurosci. 8:1534-1541(2005).
Cited for: FUNCTION, MUTAGENESIS OF ASN-23 AND ASN-79, AND GLYCOSYLATION ATASN-23 AND ASN-79.
PubMed: 16234806