LC7L3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LC7L3_MOUSE
• UniProt AC: Q5SUF2
• Protein Name: Luc7-like protein 3
• Gene Name: Luc7l3
• Organism: Mus musculus (Mouse).
• Sequence Length: 432
• Subcellular Localization: Nucleus speckle.
• Protein Description: Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity)..
• Protein Sequence: MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRDRRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKKGSDDKKSSVKSSSREKQSEDTNPESKESDTKNEVNGTSEDIKSEGDTQSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MISAAQLL -------CCCHHHHH	5.01	-
3	Phosphorylation	-----MISAAQLLDE -----CCCHHHHHHH	19.09	-
110	Phosphorylation	GHARLALSQNQQSSG HHHHHHHCCCCCCCC	22.83	29472430
115	Phosphorylation	ALSQNQQSSGAAGPT HHCCCCCCCCCCCCC	22.45	29472430
116	Phosphorylation	LSQNQQSSGAAGPTG HCCCCCCCCCCCCCC	28.28	29472430
122	Phosphorylation	SSGAAGPTGKNEEKI CCCCCCCCCCCHHHH	60.93	29472430
160	Ubiquitination	EEAQGMMKLVEQLKE HHHHHHHHHHHHHHH	40.25	-
226	Phosphorylation	GYAKIKATVEELKEK CHHHHHHHHHHHHHH	24.37	21183079
231	Acetylation	KATVEELKEKLRKRT HHHHHHHHHHHHHHC	56.96	-
238	Phosphorylation	KEKLRKRTEEPDRDE HHHHHHHCCCCCHHH	47.97	25521595
295	Phosphorylation	ERRKRSRSRSRHSSR HHHHHHHHHHHHHHH	35.54	20531401
300	Phosphorylation	SRSRSRHSSRTSDRR HHHHHHHHHHHHCCH	22.02	20531401
301	Phosphorylation	RSRSRHSSRTSDRRC HHHHHHHHHHHCCHH	33.19	25266776
304	Phosphorylation	SRHSSRTSDRRCSRS HHHHHHHHCCHHHHC	28.19	19854140
333	Phosphorylation	RSRDRRRSRSHDRSE HHHHHHHHHHHCHHH	36.00	23684622
335	Phosphorylation	RDRRRSRSHDRSERK HHHHHHHHHCHHHHH	30.87	23684622
367	Phosphorylation	SYKHRSKSRDREQDR HHHHHHHHHHHHHHH	40.43	29899451
393	Phosphorylation	DKKSSVKSSSREKQS CHHHHHHHHHHHHHC	31.24	29895711
394	Phosphorylation	KKSSVKSSSREKQSE HHHHHHHHHHHHHCC	27.91	30635358
395	Phosphorylation	KSSVKSSSREKQSED HHHHHHHHHHHHCCC	52.10	18779572
400	Phosphorylation	SSSREKQSEDTNPES HHHHHHHCCCCCCCC	48.81	23684622
403	Phosphorylation	REKQSEDTNPESKES HHHHCCCCCCCCHHC	48.93	27841257
410	Phosphorylation	TNPESKESDTKNEVN CCCCCHHCCCCCCCC	55.08	25619855
412	Phosphorylation	PESKESDTKNEVNGT CCCHHCCCCCCCCCC	45.08	25619855
419	Phosphorylation	TKNEVNGTSEDIKSE CCCCCCCCHHHHHHC	24.60	25619855
420	Phosphorylation	KNEVNGTSEDIKSEG CCCCCCCHHHHHHCC	34.37	23684622
425	Phosphorylation	GTSEDIKSEGDTQSN CCHHHHHHCCCCCCC	47.33	25521595
429	Phosphorylation	DIKSEGDTQSN---- HHHHCCCCCCC----	44.76	25521595
431	Phosphorylation	KSEGDTQSN------ HHCCCCCCC------	46.75	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LC7L3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LC7L3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LC7L3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LC7L3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425 AND SER-431, ANDMASS SPECTROMETRY.
PubMed: 17242355