TPSN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPSN_MOUSE
• UniProt AC: Q9R233
• Protein Name: Tapasin
• Gene Name: Tapbp
• Organism: Mus musculus (Mouse).
• Sequence Length: 465
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
• Protein Description: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)..
• Protein Sequence: MKPLLLLVAVALGLATVVSVVSAGPEAIECWFVEDAGGGGLSKKPATLLLRHGPRGPPPRPDLDPKLYFKVDDPAGMLLAAFRRYPAGASAPHCEMSRFIPFPASAKWARSLSPEQNCPRALDGDWLLVSVSSTLFSLSSLLRPQPEPLREPVVITMATVVLTVLTHNPAPRVQLGKDAVLDLRFAYAPSALEGSPSLDAGPPPFGLEWRRQHRGKGHLLLAATPGLAGRMPPAQEKATAFAAWDDDEPWGPWTGNGTFWLPAVKPSQEGVYLATVHLPYLQGQVSLELTVHKAPRVSLTPAPVVWAAPGEAPPELLCLASHFFPAEGLEVKWELRGGPGGSSRKVEGKTWLSTIRHHSDGSVSQSGHLQLPPVTAKQHGVHYVCRVYHSSLPASGRSADVTLEVAGFSGPSIEDGIGLFLSAFLLLGLLKVLGWLAAYWTIPEVSKEKATAASLTIPRNSKKSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Phosphorylation	ASAKWARSLSPEQNC CCHHHHHHCCCCCCC	26.00	30635358
113	Phosphorylation	AKWARSLSPEQNCPR HHHHHHCCCCCCCCC	27.86	30635358
118	Glutathionylation	SLSPEQNCPRALDGD HCCCCCCCCCCCCCC	2.11	24333276
177	Ubiquitination	APRVQLGKDAVLDLR CCCCCCCCCCEEEEE	51.62	-
224	Phosphorylation	GHLLLAATPGLAGRM CEEEEEECCCCCCCC	16.57	-
256	N-linked_Glycosylation	PWGPWTGNGTFWLPA CCCCCCCCCEEEECC	38.67	-
449	Ubiquitination	IPEVSKEKATAASLT CCHHCHHHCCCCCCC	55.57	-
451	Phosphorylation	EVSKEKATAASLTIP HHCHHHCCCCCCCCC	33.55	28059163
454	Phosphorylation	KEKATAASLTIPRNS HHHCCCCCCCCCCCC	24.47	28833060
456	Phosphorylation	KATAASLTIPRNSKK HCCCCCCCCCCCCCC	26.83	27180971
461	Phosphorylation	SLTIPRNSKKSQ--- CCCCCCCCCCCC---	42.62	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPSN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPSN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPSN_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAP1_MOUSE	Tap1	physical	9973410
TAP2_MOUSE	Tap2	physical	9973410
HA11_MOUSE	H2-D1	physical	9973410
HA2B_MOUSE	H2-Aa	physical	9973410

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.