dbPTM

HMGCL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HMGCL_MOUSE
UniProt AC	P38060
Protein Name	Hydroxymethylglutaryl-CoA lyase, mitochondrial
Gene Name	Hmgcl
Organism	Mus musculus (Mouse).
Sequence Length	325
Subcellular Localization	Mitochondrion matrix . Peroxisome . Unprocessed form is peroxisomal.
Protein Description	Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism (By similarity)..
Protein Sequence	MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQATCKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	RRLVGLTSLRAVSTS HHHHCHHHEEEEECC	22.39	27600695
31	Ubiquitination	SSMGTLPKQVKIVEV CCCCCCCCEEEEEEE	71.48	27667366
48	Succinylation	RDGLQNEKSIVPTPV CCCCCCCCCCCCCCC	53.70	-
48	Glutarylation	RDGLQNEKSIVPTPV CCCCCCCCCCCCCCC	53.70	24703693
48	Malonylation	RDGLQNEKSIVPTPV CCCCCCCCCCCCCCC	53.70	26320211
48	Succinylation	RDGLQNEKSIVPTPV CCCCCCCCCCCCCCC	53.70	23806337
48	Acetylation	RDGLQNEKSIVPTPV CCCCCCCCCCCCCCC	53.70	23806337
56	Ubiquitination	SIVPTPVKIRLIDML CCCCCCCCHHHHHHH	24.26	27667366
80	Acetylation	ATSFVSPKWVPQMAD ECCCCCCCCCCCCCC	54.00	23576753
93	Acetylation	ADHSDVLKGIQKFPG CCHHHHHHHHHHCCC	54.54	23864654
97	Ubiquitination	DVLKGIQKFPGINYP HHHHHHHHCCCCCCC	52.16	22790023
111	Succinylation	PVLTPNMKGFEEAVA CCCCCCCCCHHHHHH	68.06	24315375
111	Acetylation	PVLTPNMKGFEEAVA CCCCCCCCCHHHHHH	68.06	23576753
137	Succinylation	VSELFTRKNANCSIE HHHHHHHCCCCCCHH	58.30	-
137	Glutarylation	VSELFTRKNANCSIE HHHHHHHCCCCCCHH	58.30	24703693
137	Malonylation	VSELFTRKNANCSIE HHHHHHHCCCCCCHH	58.30	26320211
137	Succinylation	VSELFTRKNANCSIE HHHHHHHCCCCCCHH	58.30	23806337
137	Acetylation	VSELFTRKNANCSIE HHHHHHHCCCCCCHH	58.30	23576753
137	Ubiquitination	VSELFTRKNANCSIE HHHHHHHCCCCCCHH	58.30	-
141	S-palmitoylation	FTRKNANCSIEESFQ HHHCCCCCCHHHHHH	3.94	28526873
141	S-nitrosylation	FTRKNANCSIEESFQ HHHCCCCCCHHHHHH	3.94	22178444
141	S-nitrosocysteine	FTRKNANCSIEESFQ HHHCCCCCCHHHHHH	3.94	-
170	S-palmitoylation	SVRGYVSCALGCPYE CCCCCHHHHCCCCCC	2.30	28526873
174	S-palmitoylation	YVSCALGCPYEGKVS CHHHHCCCCCCCCCC	3.18	28526873
179	Succinylation	LGCPYEGKVSPAKVA CCCCCCCCCCHHHHH	27.83	-
179	Malonylation	LGCPYEGKVSPAKVA CCCCCCCCCCHHHHH	27.83	26320211
179	Acetylation	LGCPYEGKVSPAKVA CCCCCCCCCCHHHHH	27.83	23576753
179	Succinylation	LGCPYEGKVSPAKVA CCCCCCCCCCHHHHH	27.83	23806337
190	Acetylation	AKVAEVAKKLYSMGC HHHHHHHHHHHHCCC	48.78	23864654
190	Succinylation	AKVAEVAKKLYSMGC HHHHHHHHHHHHCCC	48.78	23954790
191	Acetylation	KVAEVAKKLYSMGCY HHHHHHHHHHHCCCE	42.81	7625235
307	S-nitrosocysteine	LEAGDFICQALNRKT HHHHHHHHHHHCCCC	1.63	-
307	S-nitrosylation	LEAGDFICQALNRKT HHHHHHHHHHHCCCC	1.63	22178444
307	S-palmitoylation	LEAGDFICQALNRKT HHHHHHHHHHHCCCC	1.63	28526873
323	Glutathionylation	SKVAQATCKL----- HHHHHHHHCC-----	4.78	24333276
324	Malonylation	KVAQATCKL------ HHHHHHHCC------	53.53	26320211
324	Glutarylation	KVAQATCKL------ HHHHHHHCC------	53.53	24703693
324	Acetylation	KVAQATCKL------ HHHHHHHCC------	53.53	23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HMGCL_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HMGCL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HMGCL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HMGCL_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HMGCL_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48, AND MASS SPECTROMETRY.	16916647 [Abstract]