KITH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KITH_MOUSE
• UniProt AC: P04184
• Protein Name: Thymidine kinase, cytosolic
• Gene Name: Tk1
• Organism: Mus musculus (Mouse).
• Sequence Length: 233
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MSYINLPTVLPSSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNSFSTHDRNTMDALPACMLRDVTQESLGVAVIGIDEGQFFPDIVDFCEMMANEGKTVIVAALDGTFQRKAFGSILNLVPLAESVVKLTAVCMECFREAAYTKRLGLEKEVEVIGGADKYHSVCRLCYFKKSSAQTAGSDNKNCLVLGQPGEALVVRKLFASQQVLQYNSAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSYINLPTV ------CCCCCCCCC	34.42	-
2	Phosphorylation	------MSYINLPTV ------CCCCCCCCC	34.42	25619855
3	Phosphorylation	-----MSYINLPTVL -----CCCCCCCCCC	7.79	25619855
8	Phosphorylation	MSYINLPTVLPSSPS CCCCCCCCCCCCCCC	37.53	25619855
12	Phosphorylation	NLPTVLPSSPSKTRG CCCCCCCCCCCCCCC	51.20	27566939
13	Phosphorylation	LPTVLPSSPSKTRGQ CCCCCCCCCCCCCCE	31.11	27566939
15	Phosphorylation	TVLPSSPSKTRGQIQ CCCCCCCCCCCCEEE	48.91	27566939
16	Ubiquitination	VLPSSPSKTRGQIQV CCCCCCCCCCCEEEE	45.70	-
17	Phosphorylation	LPSSPSKTRGQIQVI CCCCCCCCCCEEEEE	44.35	29895711
127	Phosphorylation	IVAALDGTFQRKAFG EEEEECCCHHHHHHH	19.09	22817900
131	Ubiquitination	LDGTFQRKAFGSILN ECCCHHHHHHHHHHH	36.97	-
135	Phosphorylation	FQRKAFGSILNLVPL HHHHHHHHHHHHHHH	19.90	26745281
203	Ubiquitination	QTAGSDNKNCLVLGQ CCCCCCCCCEEECCC	54.77	-
229	Phosphorylation	ASQQVLQYNSAN--- HHHHHHHHHCCC---	13.61	26745281
231	Phosphorylation	QQVLQYNSAN----- HHHHHHHCCC-----	25.01	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Fzr1	Q9R1K5	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
13	S	Phosphorylation	Phosphorylated on Ser-13 in mitosis.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KITH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KITH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.