dbPTM

HFE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HFE_MOUSE
UniProt AC	P70387
Protein Name	Hereditary hemochromatosis protein homolog
Gene Name	Hfe
Organism	Mus musculus (Mouse).
Sequence Length	359
Subcellular Localization	Cell membrane Single-pass type I membrane protein .
Protein Description	Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin..
Protein Sequence	MSLSAGLPVRPLLLLLLLLWSVAPQALPPRSHSLRYLFMGASEPDLGLPLFEARGYVDDQLFVSYNHESRRAEPRAPWILEQTSSQLWLHLSQSLKGWDYMFIVDFWTIMGNYNHSKVTKLGVVSESHILQVVLGCEVHEDNSTSGFWRYGYDGQDHLEFCPKTLNWSAAEPGAWATKVEWDEHKIRAKQNRDYLEKDCPEQLKRLLELGRGVLGQQVPTLVKVTRHWASTGTSLRCQALDFFPQNITMRWLKDNQPLDAKDVNPEKVLPNGDETYQGWLTLAVAPGDETRFTCQVEHPGLDQPLTASWEPLQSQAMIIGIISGVTVCAIFLVGILFLILRKRKASGGTMGGYVLTDCE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLSAGLPV ------CCCCCCCCH	30.91	25338131
42	Phosphorylation	RYLFMGASEPDLGLP HEEECCCCCCCCCCC	43.89	-
114	N-linked_Glycosylation	WTIMGNYNHSKVTKL HHHHCCCCCCCCEEE	36.64	-
142	N-linked_Glycosylation	GCEVHEDNSTSGFWR CCEEECCCCCCCCEE	44.17	-
166	N-linked_Glycosylation	EFCPKTLNWSAAEPG EECCCCCCCCCCCCC	35.57	-
246	N-linked_Glycosylation	ALDFFPQNITMRWLK ECCCCCCCEEEEEHH	31.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HFE_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HFE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HFE_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HFE_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HFE_MOUSE

Related Literatures of Post-Translational Modification