KLH40_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH40_MOUSE
• UniProt AC: Q9D783
• Protein Name: Kelch-like protein 40 {ECO:0000305}
• Gene Name: Klhl40 {ECO:0000312|MGI:MGI:1919580}
• Organism: Mus musculus (Mouse).
• Sequence Length: 621
• Subcellular Localization: Cytoplasm . Cytoplasm, myofibril, sarcomere, A band . Cytoplasm, myofibril, sarcomere, I band .
• Protein Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. [PubMed: 25940086 The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex]
• Protein Sequence: MTLGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLAEPDSAGEVRLEEVSPDVVSQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLAVAARDFICARFPLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDAEAQAERQRALPTVFESVRCRLLPRAFLETRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKGEQTARAKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPYAVYGHTVLSHMDLVYVIGGKGKDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIFVAAGVTDTGLTSSSEVYSIADNKWTSFEAFPQERSSLSLVSLAGTLYALGGFATLETESGELVPTELNDIWRYNEDEKKWEGVLREIAYAAGATFLPVRLNVVRLTKM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
266	Phosphorylation	DAHEGRLTTLRKKKK HHCCCCHHHHHHHHH		24899341
267	Phosphorylation	AHEGRLTTLRKKKKE HCCCCHHHHHHHHHH		-
607	Phosphorylation	IAYAAGATFLPVRLN HHHHCCCCEEEEEEE		25177544

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH40_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH40_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH40_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NRAP_MOUSE	Nrap	physical	24960163
IQGA1_MOUSE	Iqgap1	physical	24960163
KANK2_MOUSE	Kank2	physical	24960163
KLH41_MOUSE	Klhl41	physical	24960163
TBA1B_MOUSE	Tuba1b	physical	24960163
TBB1_MOUSE	Tubb1	physical	24960163
G3P_MOUSE	Gapdh	physical	24960163
ACTS_MOUSE	Acta1	physical	24960163

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.