NRAP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRAP_MOUSE
• UniProt AC: Q80XB4
• Protein Name: Nebulin-related-anchoring protein
• Gene Name: Nrap {ECO:0000312|MGI:MGI:1098765}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1728
• Subcellular Localization: Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle.
• Protein Description: May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix..
• Protein Sequence: MNVQACSRCGYGVYPAEKISCIDQTWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAHNPKNNTFTSVYHTPLNLTLKKSVAAMGGIDGKEDGEPFKSVLHWDMKSKAGAGAASRLMNERDYWPGYAEGNTWCPGALPDPEIVRMVEARQSLGEGYTEDREQQQGKGSFPAMITPAYQRAKAANQLASQVQYKRGHDERVSTFTPVADTPELLRAKAGGQLQNDVRYTEDGGQQRGKGSFPAMITPAYQIAKRATELASDVRYHQQYHREMKGMASPVGAEGGMTKDSVDRCGQVYSEECDEPRGKGSFPAMITPAYQNAKKANELVSDIKYRQDFHKMKGAAHFHSLAAQDNLVLKRAQSVSKLVSEVEYKKGLENSKGHSINYCETPQFRNVSKISKFTSDNKYKENYQTQLRGHYDGVGMDRRMLHALKVGSLASNVAYKADYKHDVVDYNYLATATPFYQTTMRLVPLKDVNYRQNIDRMKFSSVTNTPQIVQAKINAQQLSHVNYRADYERNKLNYTLPQDAPQLLKAKANAELFSEVKYKEGWQKTKGKGFEMKLDAMSLLAAKASGELASSVKYKEEYEKMKGRALGATDSKLLHSLQVAKMSSEVEYKKGFEESKTHFNLPMDMVNLRHAKKAQALASDLDYRKKLHDYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMRGVGWLTEGSLNLEQAKKAGQLISEKNYRQRVDELKFTSVADSSQMEHAKKSQGLQNAVAYKAGNEQSVHQYTISKDEPLFLRARANAAQLSETLYKSSWEKQKAKGFELRLDSLAFLTAKAKRDLASEVKYKEDYERSRGKLIGAKSAQGDSQMSHSLQMSKLQSDLEYKKGFEDTRSQCHISLDMVHLVHARQAQHLATDVGYRTASHCFTALPTDMKVEWAKKAYGLQSDNQYRADMKWMKGTGWVATGSLHVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENVKHHYTQTADLPEVLLAKLNAMNISETRYKESWSRLRDGGYKLRLDALPFQAAKASSEVISDYKYKEAFERMKGQMLGSRSLEDDLSLAHSVHATSLQSDVNYKKGFEHAKAHFHLPLDMVTLVHAKKAQTLASDQDYRHPLPQHTVLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGVPCVVPGTLEIEGRKKASELISESKYRQHPGSFKYTAVTDTPNLLHAKYSNQITNERLYKAAGEDARHQYTMTLGLPEFIRAKTNAANLSEAKYKEAWHNLRAQGYKLTIDALPFQAARASGDIASDFLYRHEFVKERGQLIGVRNVSDDPRLLHCLRMGQLQSENQYRKEAASSQAQCHLPMDMMYLVHARKAQALASDHDYRTQCHEFTALPEDLKMAWAKKAHALQSEFRYKADLMGMKGTGWLALQSPQIESAKKAGDLISETKYRKKPDSIKFTTVVDSPDLIHAKESYMHCNERLYRLGDAASLHRYTPIPDHPDFTRARMNAMHLSDKVYRNAWEQSRAGGYDFRLDAIPFQTARVSRDIASDFRYKEAFLRDRGLQIGYRSISDDPRTTHFLRVGRLQSDNEYRKAFAKGRSQFHSRADQPGFLQAKRSQQLASDVLYRQPLPQHTSDPEQLGLKHARKAHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANRRGPGIRGASVEPEAAAALGDHQSRGVNPDASEILHIHKKKTLLM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Ubiquitination	TPLNLTLKKSVAAMG CCCCEEECHHHHHHC	37.45	22790023
79	Phosphorylation	LNLTLKKSVAAMGGI CCEEECHHHHHHCCC	18.53	22817900
89	Ubiquitination	AMGGIDGKEDGEPFK HHCCCCCCCCCCCCC	49.21	22790023
150	Phosphorylation	RMVEARQSLGEGYTE HHHHHHHHHCCCCCC	32.56	22817900
165	Ubiquitination	DREQQQGKGSFPAMI HHHHHCCCCCCCHHC	47.22	22790023
180	Ubiquitination	TPAYQRAKAANQLAS CHHHHHHHHHHHHHH	50.66	22790023
192	Ubiquitination	LASQVQYKRGHDERV HHHHHHHHCCCCCCC	34.51	22790023
203	Phosphorylation	DERVSTFTPVADTPE CCCCCEEEECCCCHH	19.55	22817900
208	Phosphorylation	TFTPVADTPELLRAK EEEECCCCHHHHHHH	14.66	-
215	Ubiquitination	TPELLRAKAGGQLQN CHHHHHHHCCCCCCC	40.92	22790023
275	Phosphorylation	REMKGMASPVGAEGG HHHCCCCCCCCCCCC	15.95	23737553
278 (in isoform 4)	Phosphorylation	-	22.69	29514104
284	Phosphorylation	VGAEGGMTKDSVDRC CCCCCCCCHHHHHCC	34.67	27742792
287	Phosphorylation	EGGMTKDSVDRCGQV CCCCCHHHHHCCCCE	27.72	27742792
346	Phosphorylation	KGAAHFHSLAAQDNL CCHHHHHHHHHHCCH	20.82	22817900
360 (in isoform 3)	Phosphorylation	-	27.63	29514104
360 (in isoform 2)	Phosphorylation	-	27.63	29514104
360	Phosphorylation	LVLKRAQSVSKLVSE HHHHHHHHHHHHHHH	27.63	23737553
362	Phosphorylation	LKRAQSVSKLVSEVE HHHHHHHHHHHHHHH	26.06	23737553
434	Phosphorylation	LHALKVGSLASNVAY HHHHHHHHHHHCCCH	24.61	25619855
437	Phosphorylation	LKVGSLASNVAYKAD HHHHHHHHCCCHHCC	36.81	25619855
441	Phosphorylation	SLASNVAYKADYKHD HHHHCCCHHCCCCCC	11.48	25619855
487	Phosphorylation	IDRMKFSSVTNTPQI CCCCCCCCCCCCHHH	35.77	24723360
491	Phosphorylation	KFSSVTNTPQIVQAK CCCCCCCCHHHHHHH	13.75	24723360
579	Acetylation	GELASSVKYKEEYEK CHHHHHCHHHHHHHH	53.18	15612585
610	Phosphorylation	LQVAKMSSEVEYKKG HHHHHHCCCCCHHCC	42.01	23684622
621	Phosphorylation	YKKGFEESKTHFNLP HHCCCCCCCCCCCCC	35.34	23684622
793	Acetylation	SWEKQKAKGFELRLD HHHHHHHCCCEEEHH	71.78	15614349
1078	Phosphorylation	GQMLGSRSLEDDLSL CCCCCCCCHHHHHHH	37.50	16141072
1223	Ubiquitination	TPNLLHAKYSNQITN CCCCCCHHHCCCCCC	38.16	22790023
1405	Phosphorylation	KKAHALQSEFRYKAD HHHHHHHCHHHHHHH	39.28	22499769
1417	Acetylation	KADLMGMKGTGWLAL HHHHCCCCCCCEEEC	47.82	19864985
1484	Phosphorylation	YRLGDAASLHRYTPI HHHCCHHHHCCCCCC	26.82	22817900
1659	Phosphorylation	YKSDLNLTRGVGWTP CCCCCCCCCCCCCCC	25.05	26239621
1693	Phosphorylation	GPGIRGASVEPEAAA CCCCCCCCCCHHHHH	29.82	27742792

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Klhl41	A2AUC9	PMID:30986853

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRAP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRAP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLNC_MOUSE	Flnc	physical	12692149
KLH41_MOUSE	Klhl41	physical	12692149
ACTN3_MOUSE	Actn3	physical	12692149

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.