TBB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBB1_MOUSE
• UniProt AC: A2AQ07
• Protein Name: Tubulin beta-1 chain
• Gene Name: Tubb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 451
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)..
• Protein Sequence: MREIVHIQIGQCGNQIGAKFWEVIGEEHGIDCAGSYCGTSALQLERISVYYNEAYGKKYVPRAVLVDLEPGTMDSIRSSRLGVLFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVMDVVRRESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRILNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENTDACFCIDNEALYDICFRTLRLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNIMAACDPRRGRYLTVACIFRGKMSTKEVDQQLLSIQTRNSNCFVEWIPNNVKVAVCDIPPRGLNMAATFLGNNTAIQELFTRVSEHFSAMFRRRAFVHWYTSEGMDISEFGEAESDIHDLVSEYQQFQDVRAGLEDSEEDVEEAEVEAEDKDH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	ALQLERISVYYNEAY HHHHEEEEEEEHHHC	15.41	22817900
106	Phosphorylation	NNWAKGHYTEGAELI CCCCCCCCCHHHHHH	18.37	22817900
107	Phosphorylation	NWAKGHYTEGAELIE CCCCCCCCHHHHHHH	23.44	22817900
172	Phosphorylation	NSFSVMPSPKVSDTV HHCCCCCCCCCCCCC	21.18	22817900
208	Phosphorylation	CIDNEALYDICFRTL EECHHHHHHHHHHEE	15.43	22817900
252	Acetylation	QLNADLRKLAVNMVP CCCHHHHHHHHHCCC	48.36	15614601
252	Ubiquitination	QLNADLRKLAVNMVP CCCHHHHHHHHHCCC	48.36	27667366
252	Succinylation	QLNADLRKLAVNMVP CCCHHHHHHHHHCCC	48.36	-
278	Phosphorylation	APLTAQGSQQYRALS CCCCCCCHHHHHHHH	11.30	29899451
435	Phosphorylation	VRAGLEDSEEDVEEA HHHCCCCCHHHHHHH	33.25	25521595
440	5-glutamyl polyglutamate	EDSEEDVEEAEVEAE CCCHHHHHHHHHHHC	64.90	-
440	Formation of an isopeptide bond	EDSEEDVEEAEVEAE CCCHHHHHHHHHHHC	64.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
172	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
172	S	Phosphorylation	Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBP10_MOUSE	Ranbp10	physical	18347012

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.