AHR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AHR_MOUSE
• UniProt AC: P30561
• Protein Name: Aryl hydrocarbon receptor
• Gene Name: Ahr
• Organism: Mus musculus (Mouse).
• Sequence Length: 848
• Subcellular Localization: Cytoplasm . Nucleus . Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
• Protein Description: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. [PubMed: 28396409]
• Protein Sequence: MSSGANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRNGGQDQCRAQIRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPDSAQGVDEAHGPPQAAVYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCTRGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFRLFAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSTSLPFMFATGEAVLYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPSSLMSALIQQDESIYLCPPSSPAPLDSHFLMGSVSKCGSWQDSFAAAGSEAALKHEQIGHAQDVNLALSGGPSELFPDNKNNDLYNIMRNLGIDFEDIRSMQNEEFFRTDSTAAGEVDFKDIDITDEILTYVQDSLNNSTLMNSACQQQPVTQHLSCMLQERLQLEQQQQLQQPPPQALEPQQQLCQMVCPQQDLGPKHTQINGTFASWNPTPPVSFNCPQQELKHYQLFSSLQGTAQEFPYKPEVDSVPYTQNFAPCNQPLLPEHSKSVQLDFPGRDFEPSLHPTTSNLDFVSCLQVPENQSHGINSQSTMVSPQAYYAGAMSMYQCQPGPQRTPVDQTQYSSEIPGSQAFLSKVQSRGIFNETYSSDLSSIGHAAQTTGHLHHLAEARPLPDITPGGFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSGANITY ------CCCCCCCCC	37.16	29550500
3	Phosphorylation	-----MSSGANITYA -----CCCCCCCCCC	40.40	29550500
8	Phosphorylation	MSSGANITYASRKRR CCCCCCCCCCCCCCC	16.91	29550500
9	Phosphorylation	SSGANITYASRKRRK CCCCCCCCCCCCCCC	9.97	29550500
11	Phosphorylation	GANITYASRKRRKPV CCCCCCCCCCCCCCC	28.11	29550500
23	Acetylation	KPVQKTVKPIPAEGI CCCCCCCCCCCCCHH	42.32	23236377
35	Phosphorylation	EGIKSNPSKRHRDRL CHHCCCCCHHHHHHH	46.72	15063792
62	Ubiquitination	FPQDVINKLDKLSVL CCHHHHHHHHHHHHH	47.11	-
67	Phosphorylation	INKLDKLSVLRLSVS HHHHHHHHHHHHHHH	25.50	14985336
80	Phosphorylation	VSYLRAKSFFDVALK HHHHHHHHHHHHHHC	30.11	54886405
87	Ubiquitination	SFFDVALKSTPADRN HHHHHHHCCCCCCCC	42.41	-
415	Phosphorylation	YEISSPFSPIMDPLP EECCCCCCCCCCCCC	19.53	19059900
432	Ubiquitination	TKSNTSRKDWAPQST CCCCCCCCCCCCCCC	58.34	-
558	Phosphorylation	EEFFRTDSTAAGEVD HHHHCCCCCCCCCCC	21.23	25338131
716	Phosphorylation	LLPEHSKSVQLDFPG CCCCCCCCEECCCCC	20.36	18846507
765	Phosphorylation	TMVSPQAYYAGAMSM CCCCHHHHHCCCCCC	6.65	51458903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
35	S	Phosphorylation	Kinase	PRKCA	P20444	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	Stub1	Q9WUD1	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AHR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AHR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AIP_MOUSE	Aip	physical	20211142
CACO1_MOUSE	Calcoco1	physical	15383530

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.