CACO1_MOUSE - dbPTM
CACO1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CACO1_MOUSE
UniProt AC Q8CGU1
Protein Name Calcium-binding and coiled-coil domain-containing protein 1
Gene Name Calcoco1
Organism Mus musculus (Mouse).
Sequence Length 691
Subcellular Localization Cytoplasm . Nucleus . Shuttles between nucleus and cytoplasm.
Protein Description Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. [PubMed: 24245781]
Protein Sequence MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPTHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEDQVTELRSRVQELEAALATARQEHSELTEQYKGLSRSHGELSEERDILSQQQGDHVARILELEDDIQTMSDKVLMKEVELDRVRDTVKALTREQEKLLRQLKEFQADKEQSEAELQTVREENCCLNTELEEAKSRQEEQGAQVQRLKDKLAHMKDTLGQAQQKVAELEPLKEQLRGVQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAEVNGRLAELSLHMKEEKCQWSKERTGLLQSMEAEKDKILKLSAEILRLEKTVQEERTQSHVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQTEKQELLEYMRKLEARLEKVADEKWTEDAATEDEEATAGLSCPASLTDSEDESPEDMRLPSYGLCESGNTSSSPPGPREPSSLVVINQPAPIAPQFSGPGEASSSDSEAEDEKSVLMAAVQSGGEEASLLLPELGSAFYDVASAFTVSSLSEASPGVPANPPWKECPICKERFPAESDKDALEGHMDGHFFFSTQDPFTFE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MEESSLSRAPS
----CCCCCCCCCCC		24.2325521595
5Phosphorylation---MEESSLSRAPSR
---CCCCCCCCCCCC		33.3725521595
11PhosphorylationSSLSRAPSRGGVNFL
CCCCCCCCCCCCCCH		42.4425266776
206PhosphorylationTEQYKGLSRSHGELS
HHHHHCHHHHCCCHH		40.1726060331
208PhosphorylationQYKGLSRSHGELSEE
HHHCHHHHCCCHHHH		32.2522817900
477PhosphorylationRELTELRSALRVLQK
HHHHHHHHHHHHHHH		44.2622942356
484UbiquitinationSALRVLQKEKEQLQT
HHHHHHHHHHHHHHH		67.6027667366
535PhosphorylationAGLSCPASLTDSEDE
CCCCCCCCCCCCCCC		19.5625293948
537PhosphorylationLSCPASLTDSEDESP
CCCCCCCCCCCCCCC		34.6825293948
539PhosphorylationCPASLTDSEDESPED
CCCCCCCCCCCCCCC		41.5325293948
543PhosphorylationLTDSEDESPEDMRLP
CCCCCCCCCCCCCCC		46.0025293948
551PhosphorylationPEDMRLPSYGLCESG
CCCCCCCCCCCCCCC		36.1025619855
552PhosphorylationEDMRLPSYGLCESGN
CCCCCCCCCCCCCCC		16.5125619855
557PhosphorylationPSYGLCESGNTSSSP
CCCCCCCCCCCCCCC		36.0225619855
560PhosphorylationGLCESGNTSSSPPGP
CCCCCCCCCCCCCCC		33.2525619855
561PhosphorylationLCESGNTSSSPPGPR
CCCCCCCCCCCCCCC		32.5825619855
562PhosphorylationCESGNTSSSPPGPRE
CCCCCCCCCCCCCCC		44.8425619855
563PhosphorylationESGNTSSSPPGPREP
CCCCCCCCCCCCCCC		34.5825521595
571PhosphorylationPPGPREPSSLVVINQ
CCCCCCCCEEEEECC		31.3925293948
572PhosphorylationPGPREPSSLVVINQP
CCCCCCCEEEEECCC		35.5825293948
587PhosphorylationAPIAPQFSGPGEASS
CCCCCCCCCCCCCCC		38.5425293948
593PhosphorylationFSGPGEASSSDSEAE
CCCCCCCCCCCCCCH		26.5225293948
594PhosphorylationSGPGEASSSDSEAED
CCCCCCCCCCCCCHH		45.2525293948
595PhosphorylationGPGEASSSDSEAEDE
CCCCCCCCCCCCHHH		42.5319854140
597PhosphorylationGEASSSDSEAEDEKS
CCCCCCCCCCHHHHH		40.4325293948
633PhosphorylationSAFYDVASAFTVSSL
HHHHHHHHHHHHHCH		24.6225521595
639PhosphorylationASAFTVSSLSEASPG
HHHHHHHCHHHCCCC		31.4225521595
644PhosphorylationVSSLSEASPGVPANP
HHCHHHCCCCCCCCC		20.3825521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CACO1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CACO1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CACO1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AHR_MOUSEAhrphysical
15383530
ARNT_MOUSEArntphysical
15383530
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CACO1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563, AND MASSSPECTROMETRY.

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