ARNT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARNT_MOUSE
• UniProt AC: P53762
• Protein Name: Aryl hydrocarbon receptor nuclear translocator
• Gene Name: Arnt
• Organism: Mus musculus (Mouse).
• Sequence Length: 791
• Subcellular Localization: Nucleus.
• Protein Description: Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. [PubMed: 26245371]
• Protein Sequence: MAATTANPEMTSDVPSLGPTIASGNPGPGIQGGGAVVQRAIKRRSGLDFDDEVEVNTKFLRCDDDQMCNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRVLDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGTSSVDPVSMNRLSFLRNRCRNGLGSVKEGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNICQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIPRSQLGPTANLSLEMGTGQLPSRQQQQQHTELDMVPGRDGLASYNHSQVSVQPVASAGSEHSKPLEKSEGLFAQDRDPRFPEIYPSITADQSKGISSSTVPATQQLFSQGSSFPPNPRPAENFRNSGLTPPVTIVQPSSSAGQILAQISRHSNPAQGSAPTWTSSSRPGFAAQQVPTQATAKTRSSQFGVNNFQTSSSFSAMSLPGAPTASSGTAAYPALPNRGSNFPPETGQTTGQFQARTAEGVGVWPQWQGQQPHHRSSSSEQHVQQTQAQAPSQPEVFQEMLSMLGDQSNTYNNEEFPDLTMFPPFSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAATTANPE ------CCCCCCCHH	17.32	-
45	Phosphorylation	QRAIKRRSGLDFDDE HHHHHHHCCCCCCCC	47.98	25619855
77	Phosphorylation	DKERFARSDDEQSSA CHHHHHCCCHHHCHH	46.08	26824392
82	Phosphorylation	ARSDDEQSSADKERL HCCCHHHCHHHHHHH	25.99	28833060
83	Phosphorylation	RSDDEQSSADKERLA CCCHHHCHHHHHHHH	39.93	28833060
245	Sumoylation	DLKTGTVKKEGQQSS ECCCCCCCCCCCHHH	44.97	-
346	Phosphorylation	AIGRLQVTSSPNCTD EEECEEECCCCCCCC	15.55	26745281
347	Phosphorylation	IGRLQVTSSPNCTDM EECEEECCCCCCCCH	44.96	26745281
348	Phosphorylation	GRLQVTSSPNCTDMS ECEEECCCCCCCCHH	15.69	26745281
352	Phosphorylation	VTSSPNCTDMSNICQ ECCCCCCCCHHHCCC	41.18	26745281
355	Phosphorylation	SPNCTDMSNICQPTE CCCCCCHHHCCCCHH	26.34	26745281
605	Phosphorylation	PAENFRNSGLTPPVT CCHHHCCCCCCCCEE	30.81	26643407
608	Phosphorylation	NFRNSGLTPPVTIVQ HHCCCCCCCCEEEEC	29.13	26643407
612	Phosphorylation	SGLTPPVTIVQPSSS CCCCCCEEEECCCCC	22.62	26643407
661	Ubiquitination	VPTQATAKTRSSQFG CCCCCCCCHHHHHCC	39.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARNT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARNT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARNT_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CACO1_MOUSE	Calcoco1	physical	15383530
AHRR_MOUSE	Ahrr	physical	19251700

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.