AHRR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AHRR_MOUSE
• UniProt AC: Q3U1U7
• Protein Name: Aryl hydrocarbon receptor repressor
• Gene Name: Ahrr
• Organism: Mus musculus (Mouse).
• Sequence Length: 701
• Subcellular Localization: Cytoplasm . Nucleus . Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
• Protein Description: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site..
• Protein Sequence: MMIPSGECTYAGRKRRKPIQKRRLTMGAEKSNPSKRHRDRLNTELDHLASLLPFSPDIISKLDKLSVLRLSVSYLRVKSFFQALQETCVWSAPALSPEEHSYRGFPVQEGRLLLESLNGFALVVSAEGMIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQSPHADTDNTVLGKLLRAQEGGKGLPSEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKTPSGTALPPRLSLFCIVAPVLPSVTEMKMKSTFLKAKHRADIVVTMDSRAKAVTSLCESELHPKLNYLAGKSNGENGISLFRGQTDRSHWARALARSSCLCLRGGPDLLDPKGTSGDREEEDQKHILRRSPGAWGQREMHKYSYGLETPVHLRHLNWSTEQRSQESTTKLTRQPSKNEPSTCLVPHGSCVPYPGSQGMLSASNMASFRDSLDHPTGAYCSQMNRPLSDIHQGQVDPSTCHISQGSLGSRIPLTGMQRFTARGFSTEDAKLPSLPVTIGTPCNPVLSLDVPIKMENESGSQDIVEASTTSCLWLGTSDMARGHLVGFPARMHLKTEPDYRQQACTPHLGHGMLGTNPYSRDTVGSCREHAPLYSAHCTCLDPEPPHHLFMCSHSESQHPSLDQDCRAPIVKREPLDSPSWAAPGQVTVPRMFPKSASKTVIPSKGSDGIFLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
251	Phosphorylation	LFGQKKKTPSGTALP HHCCCCCCCCCCCCC	31.41	20139300
253	Phosphorylation	GQKKKTPSGTALPPR CCCCCCCCCCCCCCC	54.75	20139300
255	Phosphorylation	KKKTPSGTALPPRLS CCCCCCCCCCCCCEE	29.38	37009425
542	Sumoylation	LSLDVPIKMENESGS EEEECCEEEECCCCC	33.81	-
542	Sumoylation	LSLDVPIKMENESGS EEEECCEEEECCCCC	33.81	-
583	Sumoylation	FPARMHLKTEPDYRQ CCCEECCCCCCCHHH	35.84	-
583	Sumoylation	FPARMHLKTEPDYRQ CCCEECCCCCCCHHH	35.84	-
604	Phosphorylation	LGHGMLGTNPYSRDT CCCCCCCCCCCCCCC	29.11	51458911
607	Phosphorylation	GMLGTNPYSRDTVGS CCCCCCCCCCCCCCC	20.57	51458919
608	Phosphorylation	MLGTNPYSRDTVGSC CCCCCCCCCCCCCCC	25.57	51458927
660	Sumoylation	DCRAPIVKREPLDSP CCCCCCCCCCCCCCC	52.33	-
660	Sumoylation	DCRAPIVKREPLDSP CCCCCCCCCCCCCCC	52.33	-
692	Phosphorylation	ASKTVIPSKGSDGIF CCCCCCCCCCCCCCC	38.23	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AHRR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AHRR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AHRR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC4_HUMAN	HDAC4	physical	19251700
ANRA2_HUMAN	ANKRA2	physical	19251700
HDAC5_HUMAN	HDAC5	physical	19251700
ARNT_MOUSE	Arnt	physical	19251700

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.