TOR1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOR1A_MOUSE
• UniProt AC: Q9ER39
• Protein Name: Torsin-1A
• Gene Name: Tor1a
• Organism: Mus musculus (Mouse).
• Sequence Length: 333
• Subcellular Localization: Endoplasmic reticulum lumen. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesic
• Protein Description: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues..
• Protein Sequence: MKLGRAALALLLLAPCVVRAVEPISLSLALAGVLTTYISYPRLYCLFAECCGQMRSLSREALQKDLDNKLFGQHLAKKVILNAVSGFLSNPKPKKPLTLSLHGWTGTGKNFASKIIAENIYEGGLNSDYVHLFVATLHFPHASNITQYKDQLQMWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDVVDEVSYQKAIFIFLSNAGAERITDVALDFWKSGKQREEIKLRDMEPALAVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEVDEDIISKVAEEMTFFPKEEKVFSDKGCKTVFTKLDYYLDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Acetylation	LSREALQKDLDNKLF HCHHHHHHHHCCCHH	62.19	15629563
69	Acetylation	LQKDLDNKLFGQHLA HHHHHCCCHHHHHHH	44.88	15629571
77	Acetylation	LFGQHLAKKVILNAV HHHHHHHHHHHHHHH	54.67	15629579
89	Phosphorylation	NAVSGFLSNPKPKKP HHHHHHHCCCCCCCC	49.15	21454597
144	N-linked_Glycosylation	LHFPHASNITQYKDQ EECCCHHHCHHCHHH	41.95	-
159	N-linked_Glycosylation	LQMWIRGNVSACARS HHHHHHCCHHHHHHH	18.09	-
251	Phosphorylation	SVFNNKNSGFWHSSL EEEECCCCCCCCHHH	36.66	-
256	Phosphorylation	KNSGFWHSSLIDRNL CCCCCCCHHHHCHHH	19.89	-
257	Phosphorylation	NSGFWHSSLIDRNLI CCCCCCHHHHCHHHH	19.23	-
306	Phosphorylation	SKVAEEMTFFPKEEK HHHHHHHCCCCCHHH	25.96	26239621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOR1A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOR1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOR1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLH14_MOUSE	Klhl14	physical	19535332

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.