| UniProt ID | FIGL1_MOUSE | |
|---|---|---|
| UniProt AC | Q8BPY9 | |
| Protein Name | Fidgetin-like protein 1 | |
| Gene Name | Fignl1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 683 | |
| Subcellular Localization | Nucleus . Cytoplasm . Cytoplasm, perinuclear region . Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment. | |
| Protein Description | Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. [PubMed: 17352653 May play a role in the control of male meiosis dynamic] | |
| Protein Sequence | METSSSMSVETTRSVQVDEWQKNYCVVTSSICTPKQKADAYRALLLHIQYAYANSEISQVFATNLFKRYTEKYSAIIDSDNVVTGLNNYAESIFALAGSRQADSNKWQSGLSIDNVFKMSCVQEMMQAGKKFEESLLEPADASVVLCKEPTAFEVPQLSVCGGSEDADILSSSGHDTDKTQAIPGSSLRCSPFQSARLPKETNTTKTCLTSSTSLGESATAAFHMTPLFGNTEKDTQSFPKTSTGLNMFLSNLSCVPSGCENPQERKAFNDSDIIDILSNPTLNKAPSKTEDRGRREDNSLPTFKTAKEQLWVDQKKKGHQSQHTSKSSNGVMKKSLGAGRSRGIFGKFVPPVSNKQDGSEQHAKKHKSSRAGSAEPAHLTDDCLKNVEPRMVELIMNEIMDHGPPVHWDDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVGNLMSKEQCCLSDEETDLVVQQSDGFSGADMTQLCREASLGPIRSLHAADIATISPDQVRPIAYIDFENAFKTVRPTVSPKDLELYENWNETFGCGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 186 | Phosphorylation | KTQAIPGSSLRCSPF CCCCCCCCCCCCCCC | 22.35 | 26643407 | |
| 187 | Phosphorylation | TQAIPGSSLRCSPFQ CCCCCCCCCCCCCCC | 26.25 | 26643407 | |
| 191 | Phosphorylation | PGSSLRCSPFQSARL CCCCCCCCCCCCCCC | 23.47 | 26643407 | |
| 195 | Phosphorylation | LRCSPFQSARLPKET CCCCCCCCCCCCCCC | 18.74 | 26643407 | |
| 334 | Acetylation | KSSNGVMKKSLGAGR CCCCCHHHHCCCCCC | 36.48 | 15618437 | |
| 336 | Phosphorylation | SNGVMKKSLGAGRSR CCCHHHHCCCCCCCC | 26.90 | - | |
| 348 | Acetylation | RSRGIFGKFVPPVSN CCCCCCCCCCCCCCC | 32.22 | - | |
| 369 | Phosphorylation | QHAKKHKSSRAGSAE HHHHHHHHCCCCCCC | 25.44 | 26643407 | |
| 370 | Phosphorylation | HAKKHKSSRAGSAEP HHHHHHHCCCCCCCC | 30.84 | 26643407 | |
| 374 | Phosphorylation | HKSSRAGSAEPAHLT HHHCCCCCCCCCCCC | 28.60 | 25266776 | |
| 641 | Phosphorylation | AADIATISPDQVRPI CCCEEECCHHHCCEE | 20.33 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FIGL1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FIGL1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FIGL1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of FIGL1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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