CSDE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSDE1_MOUSE
• UniProt AC: Q91W50
• Protein Name: Cold shock domain-containing protein E1
• Gene Name: Csde1
• Organism: Mus musculus (Mouse).
• Sequence Length: 798
• Subcellular Localization: Cytoplasm.
• Protein Description: RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity)..
• Protein Sequence: MSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAIKLVKIKPEIHPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTSEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDARMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKDKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQIATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKAHSVNGITEEANPTIYSGKVIRPLRGVDPTQIEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGVELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPRPDRLVNRLKNITLDDASAPRLMVLRQPRGPDNSMGFGAERKIRQAGVID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFDPNLLH ------CCCCCCCCC	38.05	26643407
32	Ubiquitination	RETGVIEKLLTSYGF HHHCHHHHHHHHCCC	37.36	-
81	Acetylation	SSDRRTGKPIAIKLV ECCCCCCCEEEEEEE	32.41	-
81	Ubiquitination	SSDRRTGKPIAIKLV ECCCCCCCEEEEEEE	32.41	-
91	Ubiquitination	AIKLVKIKPEIHPEE EEEEEEECCCCCHHH	30.77	-
106	Glutathionylation	RMNGQVVCAVPHNLE HCCCEEEEECCCCCC	3.12	24333276
114	Phosphorylation	AVPHNLESKSPAAPG ECCCCCCCCCCCCCC	41.41	23984901
116	Phosphorylation	PHNLESKSPAAPGQS CCCCCCCCCCCCCCC	29.11	25619855
123	Phosphorylation	SPAAPGQSPTGSVCY CCCCCCCCCCCCEEE	30.28	25521595
125	Phosphorylation	AAPGQSPTGSVCYER CCCCCCCCCCEEEEE	47.54	25619855
127	Phosphorylation	PGQSPTGSVCYERNG CCCCCCCCEEEEECC	16.11	25619855
129	S-nitrosylation	QSPTGSVCYERNGEV CCCCCCEEEEECCEE	2.90	21278135
129	S-nitrosocysteine	QSPTGSVCYERNGEV CCCCCCEEEEECCEE	2.90	-
130	Phosphorylation	SPTGSVCYERNGEVF CCCCCEEEEECCEEE	18.77	23984901
166	Ubiquitination	NFVIDNNKHTGAVSA EEEEECCCCCCCCCH	49.12	-
239	Ubiquitination	TIKDRNGKEVATDVR EEECCCCCEEEEEEE	53.19	-
276	Phosphorylation	KVIPKVPSKNQNDPL EEECCCCCCCCCCCC	47.42	21183079
277	Ubiquitination	VIPKVPSKNQNDPLP EECCCCCCCCCCCCC	57.38	-
288	Ubiquitination	DPLPGRIKVDFVIPK CCCCCCEEEEEEECC	34.10	-
364	Ubiquitination	RDGFGFIKCVDRDAR ECCCCEEEEEECCCC	26.41	-
424	Phosphorylation	TVSFHSHSDHRFLGT EEEEEECCCCCEEEE	37.82	23684622
444	Phosphorylation	TFSNPKTTSPNKGKD ECCCCCCCCCCCCCC	48.60	25338131
445	Phosphorylation	FSNPKTTSPNKGKDK CCCCCCCCCCCCCCC	31.54	19060867
452	Acetylation	SPNKGKDKEAEDGII CCCCCCCCCCCCCEE	63.41	-
469	Phosphorylation	DDCGVKLTIAFQAKD ECCCCEEEEEEEEEC	12.44	22802335
480	Phosphorylation	QAKDVEGSTSPQIGD EEECCCCCCCCCCCC	16.53	29472430
481	Phosphorylation	AKDVEGSTSPQIGDK EECCCCCCCCCCCCE	56.11	29472430
482	Phosphorylation	KDVEGSTSPQIGDKV ECCCCCCCCCCCCEE	19.26	25521595
488	Ubiquitination	TSPQIGDKVEFSISD CCCCCCCEEEEECCC	38.15	-
492	Phosphorylation	IGDKVEFSISDKQRP CCCEEEEECCCCCCC	14.00	22802335
494	Phosphorylation	DKVEFSISDKQRPGQ CEEEEECCCCCCCHH	37.24	22802335
506	Glutathionylation	PGQQIATCVRLLGRN CHHHHHHHHHHHCCC	0.93	24333276
514	Phosphorylation	VRLLGRNSNSKRLLG HHHHCCCCCCHHHHE	40.91	25266776
516	Phosphorylation	LLGRNSNSKRLLGYV HHCCCCCCHHHHEEE	20.97	26745281
584	Phosphorylation	EKVNKAHSVNGITEE HHHCCCCCCCCCCCC	23.33	25521595
589	Phosphorylation	AHSVNGITEEANPTI CCCCCCCCCCCCCCE	29.22	23984901
682	Ubiquitination	RATVECVKDQFGFIN CCEEHHHHHHCCCEE	58.43	-
682	Acetylation	RATVECVKDQFGFIN CCEEHHHHHHCCCEE	58.43	-
695	Phosphorylation	INYEVGDSKKLFFHV EEEEECCCEEEEEEE	26.26	-
696	Ubiquitination	NYEVGDSKKLFFHVK EEEECCCEEEEEEEE	59.23	-
729	Ubiquitination	ILNQRTGKCSACNVW EEECCCCCCCCCCEE	25.14	-
743	Ubiquitination	WRVCEGPKAVAAPRP EEEECCCCCEECCCH	67.37	-
758	Acetylation	DRLVNRLKNITLDDA HHHHHHHCCCCCCCC	42.96	-
758	Ubiquitination	DRLVNRLKNITLDDA HHHHHHHCCCCCCCC	42.96	-
761	Phosphorylation	VNRLKNITLDDASAP HHHHCCCCCCCCCCC	33.26	22324799

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSDE1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSDE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSDE1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF4H_HUMAN	EIF4H	physical	26496610
ABHGA_HUMAN	ABHD16A	physical	26496610
DUS11_HUMAN	DUSP11	physical	26496610
TXND9_HUMAN	TXNDC9	physical	26496610
STRAP_HUMAN	STRAP	physical	26496610
TM131_HUMAN	TMEM131	physical	26496610
DDX41_HUMAN	DDX41	physical	26496610
PKHA3_HUMAN	PLEKHA3	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.