CY24B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CY24B_MOUSE
• UniProt AC: Q61093
• Protein Name: Cytochrome b-245 heavy chain
• Gene Name: Cybb {ECO:0000312|MGI:MGI:88574}
• Organism: Mus musculus (Mouse).
• Sequence Length: 570
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes..
• Protein Sequence: MGNWAVNEGLSIFVILVWLGLNVFLFINYYKVYDDGPKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGISDRYSIALSDIGDNENEEYLNFAREKIKNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLEEHNLDICADKIEEWGKIKECPVPKFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERNNANFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHPNTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	N-linked_Glycosylation	YDDGPKYNYTRKLLG CCCCCCCCHHHHHHH	37.51	-
138	Phosphorylation	VGISDRYSIALSDIG CCCCCCEEEEHHHCC	11.41	30635358
142	Phosphorylation	DRYSIALSDIGDNEN CCEEEEHHHCCCCCC	20.40	30635358
159	Ubiquitination	YLNFAREKIKNPEGG HHHHHHHHHCCCCCC	54.12	26194095
161	Ubiquitination	NFAREKIKNPEGGLY HHHHHHHCCCCCCEE	77.00	26194095
255	Ubiquitination	IEEWGKIKECPVPKF HHHHCCCCCCCCCCC	57.67	26194095
294	Ubiquitination	RFWRSQQKVVITKVV HHHHHCCCEEEEEEE	30.72	26194095
299	Ubiquitination	QQKVVITKVVTHPFK CCCEEEEEEECCCCC	24.47	26194095
306	Ubiquitination	KVVTHPFKTIELQMK EEECCCCCEEEEEEH	53.71	26194095
328	Ubiquitination	VGQYIFVKCPKVSKL ECEEEEEECCCCCEE	33.79	26194095
334	Ubiquitination	VKCPKVSKLEWHPFT EECCCCCEEEEECEE	54.11	26194095
373	Ubiquitination	FNACGCDKQEFQDAW HHHCCCCHHHHHHHH	56.66	-
381	Ubiquitination	QEFQDAWKLPKIAVD HHHHHHHCCCEEEEC	57.54	26194095
422	Phosphorylation	PFASILKSVWYKYCD CHHHHHHHHHHHHCC	17.90	24759943
432	Phosphorylation	YKYCDNATSLKLKKI HHHCCCCCCCCCEEE	40.63	24759943
433	Phosphorylation	KYCDNATSLKLKKIY HHCCCCCCCCCEEEE	22.54	24759943
506	Ubiquitination	KDVITGLKQKTLYGR HCHHCCCCHHCCCCC	51.60	26194095
509	Phosphorylation	ITGLKQKTLYGRPNW HCCCCHHCCCCCCCC	23.79	-
537	Glutathionylation	TTIGVFLCGPEALAE CEEEEEEECHHHHHH	6.08	24333276
567	Ubiquitination	GVHFIFNKENF---- CEEEEEECCCC----	43.20	26194095

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CY24B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CY24B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CY24B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CY24B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.