ACSL3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACSL3_MOUSE
• UniProt AC: Q9CZW4
• Protein Name: Long-chain-fatty-acid--CoA ligase 3
• Gene Name: Acsl3
• Organism: Mus musculus (Mouse).
• Sequence Length: 720
• Subcellular Localization: Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane prote
• Protein Description: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 has mainly an anabolic role in energy metabolism (By similarity). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity)..
• Protein Sequence: MNNHVSSTPSTMKLKQTINPILLYFIHFIISLYTILTYIPFYFLCESKQEKPNQIKAKPVSSKPDSAYRSINSVDGLASVLYPGCDTLDKVFMYAKNKFKNKRLLGTREILNEEDEIQPNGKIFKKVILGHYNWLSYEDVFIRALDFGNGLQMLGQKPKANIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHGLNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGVIVHTMAAVQALGVKANVEKKAHSKPLPSDIAVIMYTSGSTGIPKGVMISHSNIIASITGMARRIPRLGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSVLKPTLMAAVPEIMDRIYKNVMNKVNEMSAFQRNLFILAYNYKMEQISKGCSTPLCDRFVFRNVRRLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESTGAGTITEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQNVTMGYYKNEAKTKTDFFEDENGQRWLCTGDIGEFDPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLIDNICAYANSYHSYVIGFVVPNQKELTELARTKGFKGTWEELCNSSEMENEVLKVLSEAAISASLEKFEIPLKIRLSPDPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Ubiquitination	DKVFMYAKNKFKNKR HHHHHHHCHHHCCCE	43.09	22790023
353	Phosphorylation	GCRIGYSSPQTLADQ CCCCCCCCCHHHHHC	16.73	25338131
591	Phosphorylation	VKLQAGEYVSLGKVE EEECCCCEEEHHHHH	8.40	22817900
596	Ubiquitination	GEYVSLGKVEAALKN CCEEEHHHHHHHHHC	42.04	-
633	Phosphorylation	VPNQKELTELARTKG CCCHHHHHHHHHHCC	30.00	21659605
679	Ubiquitination	EKFEIPLKIRLSPDP HHCCCCEEEEECCCC	22.04	22790023
683	Phosphorylation	IPLKIRLSPDPWTPE CCEEEEECCCCCCCC	19.87	27180971
688	Phosphorylation	RLSPDPWTPETGLVT EECCCCCCCCCCCCC	19.35	23984901
699	Ubiquitination	GLVTDAFKLKRKELK CCCCHHHHHCHHHHH	55.61	22790023
706	Malonylation	KLKRKELKTHYQADI HHCHHHHHHHHHHHH	34.06	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACSL3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACSL3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACSL3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACSL3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.