| UniProt ID | SPTC2_MOUSE | |
|---|---|---|
| UniProt AC | P97363 | |
| Protein Name | Serine palmitoyltransferase 2 | |
| Gene Name | Sptlc2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 560 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass membrane protein . |
|
| Protein Description | Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity).. | |
| Protein Sequence | MRPEPGGCCCRRPMRANGCVKNGEVRNGYLRSSTATVAAAGQIHHVTENGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRHWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGAKVDIMERKSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAEVLKEYGAGVCSTRQEIGNLDKHEELEKLVARFLGVEAAMTYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPSGRGVVDYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSMSPPVMEQIITSMKCIMGQDGTSLGKECIQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | Phosphorylation | NGEVRNGYLRSSTAT CCCEECCCCCCCCCE | 11.51 | 20531401 | |
| 232 | Phosphorylation | LGVEAAMTYGMGFAT HCHHHHHHCCCCCCC | 16.52 | 28059163 | |
| 241 | Phosphorylation | GMGFATNSMNIPALV CCCCCCCCCCCCHHC | 14.62 | 28059163 | |
| 377 | N6-(pyridoxal phosphate)lysine | VMMGTFTKSFGASGG EEEEECCCCCCCCCC | 39.33 | - | |
| 377 | Other | VMMGTFTKSFGASGG EEEEECCCCCCCCCC | 39.33 | - | |
| 499 | Phosphorylation | VVVGFPATPIIESRA EEEECCCCHHHHHHH | 18.43 | 26745281 | |
| 504 | Phosphorylation | PATPIIESRARFCLS CCCHHHHHHHHHHHH | 22.34 | 26745281 | |
| 536 | Ubiquitination | VGDLLQLKYSRHRLV HHHHHHHHHCCCCCH | 28.37 | 22790023 | |
| 558 | Phosphorylation | DETTYEETED----- CCCCCCCCCC----- | 33.25 | 25338131 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPTC2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPTC2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPTC2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SURF4_HUMAN | SURF4 | physical | 26496610 | |
| CUL2_HUMAN | CUL2 | physical | 26496610 | |
| KIF3B_HUMAN | KIF3B | physical | 26496610 | |
| RPP38_HUMAN | RPP38 | physical | 26496610 | |
| SPTC1_HUMAN | SPTLC1 | physical | 26496610 | |
| SCRIB_HUMAN | SCRIB | physical | 26496610 | |
| WBP11_HUMAN | WBP11 | physical | 26496610 | |
| EFL1_HUMAN | EFTUD1 | physical | 26496610 | |
| MRM1_HUMAN | MRM1 | physical | 26496610 | |
| EME1_HUMAN | EME1 | physical | 26496610 | |
| EFCB5_HUMAN | EFCAB5 | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
