EFCB5_HUMAN - dbPTM
EFCB5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EFCB5_HUMAN
UniProt AC A4FU69
Protein Name EF-hand calcium-binding domain-containing protein 5
Gene Name EFCAB5
Organism Homo sapiens (Human).
Sequence Length 1503
Subcellular Localization
Protein Description
Protein Sequence MNESASQEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFERMEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLDKLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQRLMKEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIIVKVANTRKQALQEQFDEWILDPKGMIPKSVIQNVLQEFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKDLKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLHCDHGKVGFLDRQRTLALLELFYDHSSQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEGKSWSGEFFTCNWKMKYVTFEDEEQANLIYGNSRFTDLHSIIRNIQSCKEVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVSETLTSFFKEGYVETEQEKMNALEQFSQNAFQVRQRLLLEAIFQKWDSDGSGFLDLKEVDELLYTYKEGMEKESMKKAKLHIQFPKPHPGHEVRLSSKQFQNYIELVVSELRGNEDQVLESVVEFLMNALERSHIESLRNSARRKWLHQIQCAAETSGVSLEPVYSETFKALMQDAEAHGNKKISAHISLLEENLLLPEKGNVLLRNVACTLDDAQFVLNRVLYRDMKGISFTVVDEGKPIHVPQVQYHGNIFFWNQSRNKHDYNGSFLALPLQDAYMRIFGVLAVDTLRDPHEINIFLPHEIRFYQGVANVFSTAYHYVHSREHILHIVITGIGWLYDVTSSITSITTYFVEPSPAQDSDYVLRNMMVTGQLGLTEIHKNPPTIHRKSCIFRDFLFKCTDSSEVVLASACGETHIVVPLRERTGEALGVLDFNIGQNRMLLCQEYKDLQKMMKVVQVACYEILGEFSGEIKKKYILEIENVREVQRAGILFFRIMLLELQESIQLLNSMEFVSLLLYDHTLVTEPNSPQDSKSMELEANVKLVRDILKAVILFFHPELEFSSDFGSWDKCKFYVNKYLVNNICAFDPTAKHVEVNVQLIDEYIRDHSRTEVWKFGNVVIEHLYHWIHICSALMKITKQLNSGITPPLPSKTDNYMYAKMPGEGLQEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MNESASQEELRPA
--CCCCCCHHHCCHH		47.6125693802
62PhosphorylationKAMDEIKSQELNLEG
HHHHHHHHCCCCCCC		34.2522210691
77PhosphorylationQRKISPGSIKDSKTE
CCCCCCCCCCCCCCC		29.8318669648
80UbiquitinationISPGSIKDSKTEASG
CCCCCCCCCCCCCCC		54.4132015554
181PhosphorylationLLDKLLPTLVPGVEN
HHHHHHHHHCCCHHH		40.1228509920
191PhosphorylationPGVENMLTQVEKKKV
CCHHHHHHHHHHHHC		21.5728509920
204PhosphorylationKVLTEADTPSKFDPI
HCCCCCCCCCCCCCC		36.19-
359PhosphorylationSHIKDLKSEMFEELL
HHHHHHHHHHHHHHH		41.4127251275
409PhosphorylationGFLDRQRTLALLELF
CHHHHHHHHHHHHHH		14.1924043423
417PhosphorylationLALLELFYDHSSQML
HHHHHHHCHHHHHHH		25.9324043423
470PhosphorylationKVLLEMNTLLSANHA
HHHHHHHHHHHHCCC		27.9722468782
473PhosphorylationLEMNTLLSANHASKT
HHHHHHHHHCCCCHH		30.0922468782
478PhosphorylationLLSANHASKTQSKLL
HHHHCCCCHHHHHHH		28.78-
480PhosphorylationSANHASKTQSKLLES
HHCCCCHHHHHHHCC		35.2622468782
487PhosphorylationTQSKLLESPDQPKLN
HHHHHHCCCCCCCCC		33.4730622161
532 (in isoform 6)Phosphorylation-40.0830631047
533 (in isoform 6)Phosphorylation-52.2730631047
548PhosphorylationESVIEPGTHTESTLE
EEEECCCCCCHHHHC		36.0228787133
550PhosphorylationVIEPGTHTESTLEQG
EECCCCCCHHHHCCC		31.3128787133
552PhosphorylationEPGTHTESTLEQGSS
CCCCCCHHHHCCCCC		39.1728787133
553PhosphorylationPGTHTESTLEQGSSR
CCCCCHHHHCCCCCC		28.2528787133
558PhosphorylationESTLEQGSSRRLLTE
HHHHCCCCCCCCCCC		21.9928787133
559PhosphorylationSTLEQGSSRRLLTEQ
HHHCCCCCCCCCCCH		28.3928787133
632PhosphorylationEQGSRRMSAAEQGSL
HHHHHHCCHHHHCCC		23.63-
642PhosphorylationEQGSLRESVIEEPYQ
HHCCCCHHHCCCCCC		23.20-
648PhosphorylationESVIEEPYQKSEQGP
HHHCCCCCCCCCCCC		31.67-
651PhosphorylationIEEPYQKSEQGPYGE
CCCCCCCCCCCCCCC		21.4525693802
656PhosphorylationQKSEQGPYGEIISEE
CCCCCCCCCCCCCHH		33.9325693802
661PhosphorylationGPYGEIISEEQEDIG
CCCCCCCCHHHHCCC		40.5225693802
669PhosphorylationEEQEDIGSTSQSRKD
HHHHCCCCCCHHHHH		25.8125693802
670PhosphorylationEQEDIGSTSQSRKDS
HHHCCCCCCHHHHHH		26.1025693802
671PhosphorylationQEDIGSTSQSRKDSI
HHCCCCCCHHHHHHH		28.0525693802
673PhosphorylationDIGSTSQSRKDSILK
CCCCCCHHHHHHHHH		40.8525693802
677PhosphorylationTSQSRKDSILKSTKY
CCHHHHHHHHHCCCC		32.6224719451
684PhosphorylationSILKSTKYGEPITSE
HHHHCCCCCCCCCCC		27.1525693802
689PhosphorylationTKYGEPITSEYIEVP
CCCCCCCCCCEEECC		26.6525693802
690PhosphorylationKYGEPITSEYIEVPL
CCCCCCCCCEEECCC		29.1725693802
692PhosphorylationGEPITSEYIEVPLQE
CCCCCCCEEECCCCC		11.3625693802
727AcetylationEVPTLSRKDHFPETT
HCCCCCCCCCCCCCC		52.7812432243
757PhosphorylationKIEGKSWSGEFFTCN
EECCCCCCCCEEEEE		35.2225693802
792PhosphorylationSRFTDLHSIIRNIQS
CCHHHHHHHHHHHHH		27.3224719451
819 (in isoform 5)Phosphorylation-3.6930631047
820 (in isoform 5)Phosphorylation-2.2430631047
899PhosphorylationKEVDELLYTYKEGME
HHHHHHHHHHHHCCC		22.2026074081
900PhosphorylationEVDELLYTYKEGMEK
HHHHHHHHHHHCCCH		28.2526074081
901PhosphorylationVDELLYTYKEGMEKE
HHHHHHHHHHCCCHH		8.0926074081
909PhosphorylationKEGMEKESMKKAKLH
HHCCCHHHHHHEEEE		47.1426074081
1296PhosphorylationKVVQVACYEILGEFS
HHHHHHHHHHHHHCC		9.0326074081
1303PhosphorylationYEILGEFSGEIKKKY
HHHHHHCCCHHCHHE		31.0826074081
1310PhosphorylationSGEIKKKYILEIENV
CCHHCHHEEEEEECH		21.4426074081
1485PhosphorylationGITPPLPSKTDNYMY
CCCCCCCCCCCCCEE		56.7324719451
1490PhosphorylationLPSKTDNYMYAKMPG
CCCCCCCCEEECCCC		8.3622817900
1492PhosphorylationSKTDNYMYAKMPGEG
CCCCCCEEECCCCCC		7.8422817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EFCB5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EFCB5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EFCB5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of EFCB5_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EFCB5_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, AND MASSSPECTROMETRY.

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