SAC1_MOUSE - dbPTM
SAC1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAC1_MOUSE
UniProt AC Q9EP69
Protein Name Phosphatidylinositide phosphatase SAC1
Gene Name Sacm1l
Organism Mus musculus (Mouse).
Sequence Length 587
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity)..
Protein Sequence MAAAAYEHLKLHITPEKFYVEACDDGADDVLIIDRVSTEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLVVITKKMKVGECFNHAVWRATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLSMDGFYFSTTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYSGNRASFVQTRGSIPIFWSQRPNLKYKPHPQISKVANHMDGFQRHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFANMVSSLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGKVVTNQDGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKTYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQLGLLMDGFNSLLRYYKNNFSDGFRQDSIDLFLGNYSVDELESHSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGVASIGTFFIILYNGKDFVDAPRLVQKEKID
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
84S-nitrosocysteineKKMKVGECFNHAVWR
CCEEHHHHHHHHHHH		3.21-
84S-nitrosylationKKMKVGECFNHAVWR
CCEEHHHHHHHHHHH		3.2120925432
101AcetylationDFDVLSYKKTMLHLT
CCHHHCCCEEEEEEE		38.092388457
101UbiquitinationDFDVLSYKKTMLHLT
CCHHHCCCEEEEEEE		38.0922790023
150PhosphorylationLQRLSNTSPEFQEMS
HHHHHCCCHHHHHHH		27.0425338131
230PhosphorylationYYVRGIDSEGHAANF
EEEECCCCCCCCCCE		43.4925338131
246PhosphorylationETEQIVHYSGNRASF
EEEEEEEEECCCEEE		13.84-
395UbiquitinationNCMDCLDRTNVIQSL
CCHHHHCHHHHHHHH		18.4327667366
396PhosphorylationCMDCLDRTNVIQSLL
CHHHHCHHHHHHHHH		33.2429233185
401PhosphorylationDRTNVIQSLLARRSL
CHHHHHHHHHHHHHH		17.7729233185
432AcetylationEEQDEFEKTYKNAWA
HHHHHHHHHHHHHHH		63.5823954790
432UbiquitinationEEQDEFEKTYKNAWA
HHHHHHHHHHHHHHH		63.5822790023
435AcetylationDEFEKTYKNAWADNA
HHHHHHHHHHHHHHH		45.4815607629
435UbiquitinationDEFEKTYKNAWADNA
HHHHHHHHHHHHHHH		45.4822790023
445S-nitrosylationWADNANACAKQYAGT
HHHHHHHHHHHHCCC		4.9521278135
445S-nitrosocysteineWADNANACAKQYAGT
HHHHHHHHHHHHCCC		4.95-
456UbiquitinationYAGTGALKTDFTRTG
HCCCCCCCCCCCCCC		45.5827667366
456MalonylationYAGTGALKTDFTRTG
HCCCCCCCCCCCCCC		45.5826320211
456AcetylationYAGTGALKTDFTRTG
HCCCCCCCCCCCCCC		45.58-
457PhosphorylationAGTGALKTDFTRTGK
CCCCCCCCCCCCCCC		36.8823649490
460PhosphorylationGALKTDFTRTGKRTQ
CCCCCCCCCCCCCCH		30.0823649490
487PhosphorylationRYYKNNFSDGFRQDS
HHHHHCCCCCCCHHH		38.6622324799
509PhosphorylationYSVDELESHSPLSVP
CCHHHHHHCCCCCCC		41.72-
511PhosphorylationVDELESHSPLSVPRD
HHHHHHCCCCCCCCC		36.4927180971
514PhosphorylationLESHSPLSVPRDWKF
HHHCCCCCCCCCHHH		33.2029472430
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAC1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAC1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAC1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
COPD_HUMANARCN1physical
26496610
ATPB_HUMANATP5Bphysical
26496610
CDC5L_HUMANCDC5Lphysical
26496610
COPA_HUMANCOPAphysical
26496610
COPB_HUMANCOPB1physical
26496610
OST48_HUMANDDOSTphysical
26496610
RPN1_HUMANRPN1physical
26496610
COPB2_HUMANCOPB2physical
26496610
SMC4_HUMANSMC4physical
26496610
CLPX_HUMANCLPXphysical
26496610
COPE_HUMANCOPEphysical
26496610
COPZ1_HUMANCOPZ1physical
26496610
COPG1_HUMANCOPG1physical
26496610
EFR3A_HUMANEFR3Aphysical
26496610
KLDC2_HUMANKLHDC2physical
26496610
COPG2_HUMANCOPG2physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAC1_MOUSE

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Related Literatures of Post-Translational Modification

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