LC7L2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LC7L2_MOUSE
• UniProt AC: Q7TNC4
• Protein Name: Putative RNA-binding protein Luc7-like 2
• Gene Name: Luc7l2
• Organism: Mus musculus (Mouse).
• Sequence Length: 392
• Subcellular Localization: Isoform 4: Nucleus speckle. Nucleus, nucleoplasm. Colocalizes with SCNM1 and SNRNP70 in nuclear speckles.
• Protein Description: May bind to RNA via its Arg/Ser-rich domain..
• Protein Sequence: MSAQAQMRAMLDQLMGTSRDGDTTRQRIKFSDDRVCKSHLLNCCPHDVLSGTRMDLGECLKVHDLALRADYEIASKEQDFFFELDAMDHLQSFIADCDRRTEVSKKRLAETQEEISAEVAAKAERVHELNEEIGKLLAKVEQLGAEGNVEESQKVMDEVEKARAKKREAEEVYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIEIREKLEELKRVVAEKQEKRNQERLKRREEREREEREKLRRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKRRSSKERFRDQDLASRDRDRSSRDRSPRDRDRKDKKRSYESANGRSEDRRSSEEREAGEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	MLDQLMGTSRDGDTT HHHHHHCCCCCCCCH	13.46	27566939
18	Phosphorylation	LDQLMGTSRDGDTTR HHHHHCCCCCCCCHH	23.73	21082442
23	Phosphorylation	GTSRDGDTTRQRIKF CCCCCCCCHHHHEEC	29.43	28833060
24	Phosphorylation	TSRDGDTTRQRIKFS CCCCCCCHHHHEECC	29.55	28833060
266	Hydroxylation	RRSRSHSKNPKRSRS HHHHHCCCCCCHHHH	72.37	-
269	Hydroxylation	RSHSKNPKRSRSREH HHCCCCCCHHHHHHH	72.84	-
281	Phosphorylation	REHRRHRSRSMSRER HHHHHHHHHHHHHHH	23.68	23684622
283	Phosphorylation	HRRHRSRSMSRERKR HHHHHHHHHHHHHHH	23.50	23684622
285	Phosphorylation	RHRSRSMSRERKRRT HHHHHHHHHHHHHHH	32.03	23684622
305	Phosphorylation	EKRHRHRSRSSSRSR HHHHHHHHCCHHHHH	30.32	19367708
309	Phosphorylation	RHRSRSSSRSRSRSH HHHHCCHHHHHHHHH	35.21	19367708
323	Phosphorylation	HQRSRHSSRDRSRER HHHHHHHHHHHHHHH	31.88	22817900
327	Phosphorylation	RHSSRDRSRERSKRR HHHHHHHHHHHHHHH	42.66	22817900
347	Phosphorylation	FRDQDLASRDRDRSS HHHHHHHHHHCCCCC	41.85	22817900
353	Phosphorylation	ASRDRDRSSRDRSPR HHHHCCCCCCCCCCC	33.73	29899451
354	Phosphorylation	SRDRDRSSRDRSPRD HHHCCCCCCCCCCCC	38.81	19367708
358	Phosphorylation	DRSSRDRSPRDRDRK CCCCCCCCCCCCCHH	28.69	29899451
378	Phosphorylation	YESANGRSEDRRSSE HHHCCCCCCCCCCHH	45.29	21183079
383	Phosphorylation	GRSEDRRSSEEREAG CCCCCCCCHHHHHHC	42.89	23684622
384	Phosphorylation	RSEDRRSSEEREAGE CCCCCCCHHHHHHCC	41.48	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LC7L2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LC7L2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LC7L2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LC7L2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383 AND SER-384, ANDMASS SPECTROMETRY.
PubMed: 17242355