| UniProt ID | SUMO3_RAT | |
|---|---|---|
| UniProt AC | Q5XIF4 | |
| Protein Name | Small ubiquitin-related modifier 3 {ECO:0000305} | |
| Gene Name | Sumo3 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 110 | |
| Subcellular Localization | Cytoplasm. Nucleus. Nucleus, PML body. | |
| Protein Description | Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity).. | |
| Protein Sequence | MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGTASRASVPTPSHFPDICY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Acetylation | ---MSEEKPKEGVKT ---CCCCCCCCCCCC | 58.29 | 22902405 | |
| 7 | Acetylation | -MSEEKPKEGVKTEN -CCCCCCCCCCCCCC | 77.49 | 22902405 | |
| 11 | Acetylation | EKPKEGVKTENDHIN CCCCCCCCCCCCCEE | 62.06 | 22902405 | |
| 27 | Phosphorylation | KVAGQDGSVVQFKIK EEECCCCCEEEEEEE | 27.66 | 23984901 | |
| 32 | Acetylation | DGSVVQFKIKRHTPL CCCEEEEEEEECCHH | 30.17 | 72586753 | |
| 41 | Acetylation | KRHTPLSKLMKAYCE EECCHHHHHHHHHHH | 61.35 | 22648881 | |
| 41 | Ubiquitination | KRHTPLSKLMKAYCE EECCHHHHHHHHHHH | 61.35 | - | |
| 44 | Acetylation | TPLSKLMKAYCERQG CHHHHHHHHHHHHCC | 46.79 | 14497041 | |
| 44 | Ubiquitination | TPLSKLMKAYCERQG CHHHHHHHHHHHHCC | 46.79 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SUMO3_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SUMO3_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SUMO3_RAT !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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