| UniProt ID | KIF22_RAT | |
|---|---|---|
| UniProt AC | Q5I0E8 | |
| Protein Name | Kinesin-like protein KIF22 | |
| Gene Name | Kif22 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 657 | |
| Subcellular Localization | Nucleus . Cytoplasm, cytoskeleton . | |
| Protein Description | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.. | |
| Protein Sequence | MNVRAKKKPQQREMASASSGPSRSLSKGGVSRRPPLARVRVAVRLRPFMDEAKEPPCVRGIDSCSLEVANWRKYQETLKYQFDAFYGEKSTQQDVYVGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTREESAEGRPWDISVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITSFSEFEQHFLPASRNRVVGATRLNQRSSRSHAVLLVKVEQRERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAINTSLFVLGKVVDALNQGLPRIPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNFTARSKEVINRPFTNESLQPHALAPVKLPQKELLGPSEAKKAKGPEEESTGSPESTAAPASASQKLSLLQKLSNMDPAMLENLLSMERLLGSQGSQGIPLLNTPKRERMVLIKTVEEKNLEIERLKMKQKELEAKVLAQEALDPKEKENTPTILQPSSSCSGSVAKPLKKAVVMPLQRIQKQSESSNKIHLLKKGHKRKLESSHESEAVEKDEDYWEIQISPELLARGRKKLLHLLNEGSARDLRSLQRIGQKKAQLIVGWRELHGPFNEVEDLEQVEGISGKQVESFLKANLLSLAASQHSGPS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Phosphorylation | PQQREMASASSGPSR HHHHHHHHHCCCCCC | 27.63 | 28432305 | |
| 18 | Phosphorylation | QREMASASSGPSRSL HHHHHHHCCCCCCCC | 33.08 | 28432305 | |
| 19 | Phosphorylation | REMASASSGPSRSLS HHHHHHCCCCCCCCC | 55.21 | 28432305 | |
| 22 | Phosphorylation | ASASSGPSRSLSKGG HHHCCCCCCCCCCCC | 37.72 | 28432305 | |
| 24 | Phosphorylation | ASSGPSRSLSKGGVS HCCCCCCCCCCCCCC | 41.13 | 28432305 | |
| 26 | Phosphorylation | SGPSRSLSKGGVSRR CCCCCCCCCCCCCCC | 30.42 | 28432305 | |
| 401 | Phosphorylation | AKGPEEESTGSPEST CCCCCCCCCCCCCCC | 41.15 | 28432305 | |
| 402 | Phosphorylation | KGPEEESTGSPESTA CCCCCCCCCCCCCCC | 44.98 | 28432305 | |
| 404 | Phosphorylation | PEEESTGSPESTAAP CCCCCCCCCCCCCCC | 26.11 | 27097102 | |
| 407 | Phosphorylation | ESTGSPESTAAPASA CCCCCCCCCCCCCCH | 27.08 | 27097102 | |
| 408 | Phosphorylation | STGSPESTAAPASAS CCCCCCCCCCCCCHH | 25.77 | 27097102 | |
| 419 | Phosphorylation | ASASQKLSLLQKLSN CCHHHHHHHHHHHCC | 33.79 | - | |
| 444 | Phosphorylation | SMERLLGSQGSQGIP HHHHHHCCCCCCCCC | 31.19 | - | |
| 455 | Phosphorylation | QGIPLLNTPKRERMV CCCCCCCCCCCHHEE | 30.11 | 28432305 | |
| 537 | Phosphorylation | RIQKQSESSNKIHLL HHHHCCCCCCCHHHH | 44.45 | - | |
| 554 | Phosphorylation | GHKRKLESSHESEAV HHHHHCCCCCCCCCC | 47.64 | - | |
| 573 | Phosphorylation | DYWEIQISPELLARG CCEEEECCHHHHHCH | 8.92 | - | |
| 654 | Phosphorylation | SLAASQHSGPS---- HHHHHHCCCCC---- | 44.77 | 23984901 | |
| 657 | Phosphorylation | ASQHSGPS------- HHHCCCCC------- | 57.27 | 23984901 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KIF22_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KIF22_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KIF22_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of KIF22_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
