ARF2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARF2_RAT
• UniProt AC: P84082
• Protein Name: ADP-ribosylation factor 2
• Gene Name: Arf2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 181
• Subcellular Localization: Golgi apparatus.
• Protein Description: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus..
• Protein Sequence: MGNVFEKLFKSLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELTRMLAEDELRDAVLLVFVNKQDLPNAMNAAEITDKLGLHSLRQRNWYIQATCATSGDGLYEGLDWLSNQLKNQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNVFEKLF ------CCHHHHHHH	38.72	-
36	Acetylation	GKTTILYKLKLGEIV CCEEEEEEEECCCEE	35.38	31097137
73	Ubiquitination	WDVGGQDKIRPLWRH EECCCCCCCHHHHHH	32.50	-
142	Acetylation	NAAEITDKLGLHSLR CHHHHHHHHCCHHHH	35.49	66708769
142	Ubiquitination	NAAEITDKLGLHSLR CHHHHHHHHCCHHHH	35.49	-
147	Phosphorylation	TDKLGLHSLRQRNWY HHHHCCHHHHHCCCE	30.23	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARF2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARF2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARF2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ARF2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.