RPN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPN1_RAT
• UniProt AC: P07153
• Protein Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
• Gene Name: Rpn1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 605
• Subcellular Localization: Endoplasmic reticulum . Endoplasmic reticulum membrane; Single-pass type I membrane protein . Melanosome .
• Protein Description: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains..
• Protein Sequence: MEAPIVLLLLLWLALAPTPGSASSEAPPLVNEDVKRTVDLSSHLAKVTAEVVLAHPGGGSTARASSFVLALEPELESRLAHLGVQVKGEDEEDNNLEVRETKMKGKSGRFFTVKLPVALDPGSKISIVVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVRLASRNVESHTKLGNPSRSEDILDYGPFKDIPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFGLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIQVDSPYDISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRLGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKAVTSEIAVLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLSSGKRQELVTKIDHILDAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	GGSTARASSFVLALE CCCHHHHHHEEEEEC	20.82	17564427
66	Phosphorylation	GSTARASSFVLALEP CCHHHHHHEEEEECH	20.56	17564427
114	Acetylation	SGRFFTVKLPVALDP CCCEEEEEEEEEECC	43.97	22902405
185	Acetylation	RNVESHTKLGNPSRS CCHHHHCCCCCCCCC	49.31	22902405
202	Acetylation	ILDYGPFKDIPAYSQ CHHCCCCCCCCCCCC	58.86	22902405
297	N-linked_Glycosylation	YYRDEIGNVSTSHLL EECCCCCCCCCCEEE	30.17	-
508	Phosphorylation	YKQSRDISTLNSGKK HHHHCCHHHHHCCCC	31.00	25575281
509	Phosphorylation	KQSRDISTLNSGKKS HHHCCHHHHHCCCCC	30.23	25575281
512	Phosphorylation	RDISTLNSGKKSLET CCHHHHHCCCCCHHH	55.92	25575281
514	Acetylation	ISTLNSGKKSLETEH HHHHHCCCCCHHHHH	38.72	22902405
516	Phosphorylation	TLNSGKKSLETEHKA HHHCCCCCHHHHHHH	34.62	25575281
519	Phosphorylation	SGKKSLETEHKAVTS CCCCCHHHHHHHHHH	49.00	25575281
525	Phosphorylation	ETEHKAVTSEIAVLQ HHHHHHHHHHHHHHH	26.04	28432305
526	Phosphorylation	TEHKAVTSEIAVLQS HHHHHHHHHHHHHHH	22.02	28432305
533	Phosphorylation	SEIAVLQSRLKTEGS HHHHHHHHHHHCCCC	35.11	28689409
536	Succinylation	AVLQSRLKTEGSDLC HHHHHHHHCCCCCHH	43.34	26843850
536	Acetylation	AVLQSRLKTEGSDLC HHHHHHHHCCCCCHH	43.34	22902405
540	Phosphorylation	SRLKTEGSDLCDRVS HHHHCCCCCHHHHHH	22.60	25575281
551	Acetylation	DRVSEMQKLDAQVKE HHHHHHHHHHHHHHH	47.20	22902405
557	Acetylation	QKLDAQVKELVLKSA HHHHHHHHHHHHHHH	33.00	22902405
597	Acetylation	KRQELVTKIDHILDA CHHHHHHHHHHHHHH	38.36	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
65	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
66	S	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPN1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPN1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RPN1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.