PROF1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PROF1_RAT
• UniProt AC: P62963
• Protein Name: Profilin-1
• Gene Name: Pfn1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 140
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity)..
• Protein Sequence: MAGWNAYIDSLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVSITPAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNVTVTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGWNAYID ------CCCHHHHHH	31.54	-
28	Phosphorylation	AIVGYKDSPSVWAAV EEEEECCCCCEEEEC	18.21	22673903
30	Phosphorylation	VGYKDSPSVWAAVPG EEECCCCCEEEECCC	33.95	22673903
39	Phosphorylation	WAAVPGKTFVSITPA EEECCCCEEEEECHH	34.87	23984901
42	Phosphorylation	VPGKTFVSITPAEVG CCCCEEEEECHHHEE	19.29	23984901
44	Phosphorylation	GKTFVSITPAEVGVL CCEEEEECHHHEEEE	14.67	23984901
54	Acetylation	EVGVLVGKDRSSFFV HEEEEEECCCCCEEE	42.35	22902405
57	Phosphorylation	VLVGKDRSSFFVNGL EEEECCCCCEEECCE	41.45	22673903
58	Phosphorylation	LVGKDRSSFFVNGLT EEECCCCCEEECCEE	24.49	22673903
65	Phosphorylation	SFFVNGLTLGGQKCS CEEECCEEECCEEEE	25.42	23984901
70	Ubiquitination	GLTLGGQKCSVIRDS CEEECCEEEEEEEHH	31.58	-
85	Phosphorylation	LLQDGEFTMDLRTKS HCCCCEEEEEEEECC	12.89	23984901
108	Acetylation	VTVTMTAKTLVLLMG EEEEECCCEEEEHHC	32.97	-
126	Ubiquitination	VHGGLINKKCYEMAS CCCCCCCHHHHHHHH	36.91	-
129	Phosphorylation	GLINKKCYEMASHLR CCCCHHHHHHHHHHH	20.02	-
138	Phosphorylation	MASHLRRSQY----- HHHHHHHHCC-----	27.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
138	S	Phosphorylation	Kinase	ROCK1	Q63644	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
138	S	Phosphorylation	Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PROF1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of PROF1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.