| UniProt ID | TCPE_RAT | |
|---|---|---|
| UniProt AC | Q68FQ0 | |
| Protein Name | T-complex protein 1 subunit epsilon | |
| Gene Name | Cct5 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 541 | |
| Subcellular Localization | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. | |
| Protein Description | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).. | |
| Protein Sequence | MASVGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIQHLDKISDNVLVDINNPEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKEVLNAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIAQIKETGANLAICQWGFDDEANHLLLQNGLPAVRWVGGPEIELIAIATGGRIVPRFSELTSEKLGFAGVVREISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKESNPALGIDCLHKGSNDMQYQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MASVGTLAF ------CCCCCCEEE | 16.96 | - | |
| 26 | Phosphorylation | IKDQDRKSRLMGLEA EECCCHHHHHCCHHH | 31.38 | - | |
| 79 | Phosphorylation | NDGATILSMMDVDHQ CCCCEEEEECCHHHH | 14.28 | 26022182 | |
| 223 | Acetylation | GGRLEDTKLIKGVIV CCCCCCCEEEEEEEE | 61.61 | 22902405 | |
| 226 | Acetylation | LEDTKLIKGVIVDKD CCCCEEEEEEEECCC | 58.52 | 22902405 | |
| 232 | Succinylation | IKGVIVDKDFSHPQM EEEEEECCCCCCCCC | 50.18 | 26843850 | |
| 232 | Acetylation | IKGVIVDKDFSHPQM EEEEEECCCCCCCCC | 50.18 | 22902405 | |
| 269 | Phosphorylation | TKHKLDVTSVEDYKA CCCCCCCCCHHHHHH | 27.07 | 30181290 | |
| 270 | Phosphorylation | KHKLDVTSVEDYKAL CCCCCCCCHHHHHHH | 24.29 | 30181290 | |
| 284 | Acetylation | LQKYEKEKFEEMIAQ HHHHHHHHHHHHHHH | 69.97 | 22902405 | |
| 346 | Phosphorylation | GRIVPRFSELTSEKL CCEECCHHHHCCCCC | 32.73 | - | |
| 363 | Phosphorylation | AGVVREISFGTTKDK CCEEEEEECCCCCCE | 16.93 | 26022182 | |
| 366 | Phosphorylation | VREISFGTTKDKMLV EEEEECCCCCCEEEE | 28.76 | 26022182 | |
| 367 | Phosphorylation | REISFGTTKDKMLVI EEEECCCCCCEEEEE | 37.31 | 26022182 | |
| 368 | Acetylation | EISFGTTKDKMLVIE EEECCCCCCEEEEEE | 56.01 | 22902405 | |
| 485 | Phosphorylation | RARQVKESNPALGID HHHHHHHHCCCCCEE | 42.25 | 29779826 | |
| 539 | Phosphorylation | DIRKPGESEE----- HCCCCCCCCC----- | 53.60 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TCPE_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TCPE_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TCPE_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TCPE_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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