HNRPM_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNRPM_RAT
• UniProt AC: Q62826
• Protein Name: Heterogeneous nuclear ribonucleoprotein M
• Gene Name: Hnrnpm
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 690
• Subcellular Localization: Nucleus matrix .
• Protein Description: Pre-mRNA binding protein, binds avidly to poly(G) and poly(U) RNA homopolymers. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines..
• Protein Sequence: MAAGVEAAAEVAATEPKMEEESGAPCVPSGNGAPVPKGEERPTQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNLGPAGMGMEGIGFGINKIGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGSGAGGSVPGIERMGPGIDRISGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMDRMVPTGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGAGGASFDRTIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAGVEAAA ------CCCHHHHHH	16.96	-
29	Phosphorylation	SGAPCVPSGNGAPVP CCCCCCCCCCCCCCC	25.21	-
85	Phosphorylation	PFDVKWQSLKDLVKE CCCCCHHHHHHHHHH	35.95	23984901
133	Acetylation	KAAEVLNKHSLSGRP HHHHHHHHCCCCCCC	30.34	-
137	Phosphorylation	VLNKHSLSGRPLKVK HHHHCCCCCCCCCCC	35.45	23984901
144	Succinylation	SGRPLKVKEDPDGEH CCCCCCCCCCCCHHH	55.61	26843850
164	Phosphorylation	QKAGRLGSTVFVANL HHHCCCCCEEEEECC	26.45	23984901
165	Phosphorylation	KAGRLGSTVFVANLD HHCCCCCEEEEECCC	19.03	23984901
199	Succinylation	RADILEDKDGKSRGI EEEEEECCCCCCCCC	60.03	26843850
199	Acetylation	RADILEDKDGKSRGI EEEEEECCCCCCCCC	60.03	22902405
237	Acetylation	FDRPMHVKMDERALP ECCCEECCCCCCCCC	26.42	-
238	Acetylation	DRPMHVKMDERALPK CCCEECCCCCCCCCC	6.69	-
325	Phosphorylation	ENMGRFGSGMNMGRI CCCCCCCCCCCHHHH	31.96	23984901
337	Phosphorylation	GRINEILSNALKRGE HHHHHHHHHHHHHCC	26.22	23984901
357	Phosphorylation	GGSGAGGSVPGIERM CCCCCCCCCCCHHHC	24.99	-
372	Phosphorylation	GPGIDRISGAGMERM CCCCCCCCCCCHHHH	24.39	23984901
387	Ubiquitination	GAGLGHGMDRVGSEI CCCCCCCHHHCCHHH	2.17	-
392	Phosphorylation	HGMDRVGSEIERMGL CCHHHCCHHHHHHCH	32.32	29779826
396	Phosphorylation	RVGSEIERMGLVMDR HCCHHHHHHCHHHHC	30.08	-
406	Phosphorylation	LVMDRMGSVERMGSG HHHHCCCCHHCCCCC	16.09	21630457
412	Phosphorylation	GSVERMGSGIERMGP CCHHCCCCCHHHCCC	27.53	-
427	Phosphorylation	LGLDHMASSIERMGQ CCHHHHHHHHHHHHH	25.03	23984901
428	Phosphorylation	GLDHMASSIERMGQT CHHHHHHHHHHHHHH	20.94	27097102
431	Phosphorylation	HMASSIERMGQTMER HHHHHHHHHHHHHHH	32.63	-
441	Phosphorylation	QTMERIGSGVERMGA HHHHHHHCCHHHCCC	36.98	29779826
445	Phosphorylation	RIGSGVERMGAGMGF HHHCCHHHCCCCCCC	26.82	-
456	Methylation	GMGFGLERMAAPIDR CCCCCHHHCCCCHHH	25.69	-
467	Phosphorylation	PIDRVGQTIERMGSG CHHHHHHHHHHHCCC	20.90	23984901
473	Phosphorylation	QTIERMGSGVERMGP HHHHHHCCCHHHHHH	30.26	28432305
480	Phosphorylation	SGVERMGPAIERMGL CCHHHHHHHHHHCCC	22.26	-
488	Phosphorylation	AIERMGLSMDRMVPT HHHHCCCCCCCCCCC	16.95	28432305
495	Methylation	SMDRMVPTGMGAGLE CCCCCCCCCCCCCHH	28.52	-
527	Phosphorylation	ANNLERMGLERMGAN HHHHHHHCHHHCCCH	30.52	-
535	Phosphorylation	LERMGANSLERMGLE HHHCCCHHHHHHCHH	30.95	21738781
548	Phosphorylation	LERMGANSLERMGPA HHHCCCCHHHHHCCH	30.95	21738781
574	Phosphorylation	MGLAMGGAGGASFDR HCCCCCCCCCCCCCC	13.91	-
578	Phosphorylation	MGGAGGASFDRTIEM CCCCCCCCCCCEEEE	30.84	27097102
587	Phosphorylation	DRTIEMERGNFGGSF CCEEEECCCCCCCCC	44.00	-
593	Phosphorylation	ERGNFGGSFAGSFGG CCCCCCCCCCCCCCC	16.59	27097102
597	Phosphorylation	FGGSFAGSFGGAGGH CCCCCCCCCCCCCCC	19.79	27097102
625	Phosphorylation	RNLPFDFTWKMLKDK HCCCCCCHHHHHHHH	26.48	23984901
632	Acetylation	TWKMLKDKFNECGHV HHHHHHHHHHCCCCE	48.80	-
658	Acetylation	SKGCGVVKFESPEVA CCCCEEEEECCHHHH	40.79	25786129
661	Phosphorylation	CGVVKFESPEVAERA CEEEEECCHHHHHHH	29.50	27097102
697	Acetylation	A-------------- C--------------		-
700	Phosphorylation	----------------- -----------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNRPM_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNRPM_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNRPM_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEAM5_HUMAN	CEACAM5	physical	11406629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.