RAB14_RAT - dbPTM
RAB14_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAB14_RAT
UniProt AC P61107
Protein Name Ras-related protein Rab-14
Gene Name Rab14
Organism Rattus norvegicus (Rat).
Sequence Length 215
Subcellular Localization Recycling endosome . Early endosome membrane
Lipid-anchor
Cytoplasmic side . Golgi apparatus membrane
Lipid-anchor
Cytoplasmic side . Golgi apparatus, trans-Golgi network membrane
Lipid-anchor
Cytoplasmic side . Cytoplasmic vesicle, phagosome
Protein Description Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes..
Protein Sequence MATTPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MATTPYNYS
------CCCCCCCHH		21.85-
6Phosphorylation--MATTPYNYSYIFK
--CCCCCCCHHHEEE		25.3324972320
8PhosphorylationMATTPYNYSYIFKYI
CCCCCCCHHHEEEEE		9.3024972320
10PhosphorylationTTPYNYSYIFKYIII
CCCCCHHHEEEEEEE		10.4624972320
61AcetylationEVSGQKIKLQIWDTA
EECCCEEEEEEECCC		41.1822902405
61UbiquitinationEVSGQKIKLQIWDTA
EECCCEEEEEEECCC		41.18-
97PhosphorylationVYDITRRSTYNHLSS
EEECCCCHHHHHHHH		31.7722673903
98PhosphorylationYDITRRSTYNHLSSW
EECCCCHHHHHHHHH		26.9122673903
99PhosphorylationDITRRSTYNHLSSWL
ECCCCHHHHHHHHHH		11.2228689409
170AcetylationDAFLEAAKKIYQNIQ
HHHHHHHHHHHHHHC		46.9122902405
170UbiquitinationDAFLEAAKKIYQNIQ
HHHHHHHHHHHHHHC		46.91-
173PhosphorylationLEAAKKIYQNIQDGS
HHHHHHHHHHHCCCC		12.3728689409
180PhosphorylationYQNIQDGSLDLNAAE
HHHHCCCCCCCCHHH		27.3128432305
188PhosphorylationLDLNAAESGVQHKPS
CCCCHHHHCCCCCCC		39.2725575281
193UbiquitinationAESGVQHKPSAPQGG
HHHCCCCCCCCCCCC		24.47-
203PhosphorylationAPQGGRLTSEPQPQR
CCCCCCCCCCCCCCC		29.6830181290
204PhosphorylationPQGGRLTSEPQPQRE
CCCCCCCCCCCCCCC		52.4530181290
213GeranylgeranylationPQPQREGCGC-----
CCCCCCCCCC-----		4.27-
215MethylationPQREGCGC-------
CCCCCCCC-------		6.15-
215GeranylgeranylationPQREGCGC-------
CCCCCCCC-------		6.15-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAB14_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAB14_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAB14_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RAB14_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAB14_RAT

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Related Literatures of Post-Translational Modification

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