UniProt ID | PGAM1_RAT | |
---|---|---|
UniProt AC | P25113 | |
Protein Name | Phosphoglycerate mutase 1 | |
Gene Name | Pgam1 | |
Organism | Rattus norvegicus (Rat). | |
Sequence Length | 254 | |
Subcellular Localization | ||
Protein Description | Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.. | |
Protein Sequence | MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKVKK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
5 | Acetylation | ---MAAYKLVLIRHG ---CCCEEEEEEECC | 27.65 | 22902405 | |
5 | Ubiquitination | ---MAAYKLVLIRHG ---CCCEEEEEEECC | 27.65 | - | |
14 | Phosphorylation | VLIRHGESAWNLENR EEEECCCCCCCCCCC | 43.08 | 28689409 | |
23 | Phosphorylation | WNLENRFSGWYDADL CCCCCCCCCCCCCCC | 25.77 | 21738781 | |
26 | Phosphorylation | ENRFSGWYDADLSPA CCCCCCCCCCCCCCC | 12.55 | 27097102 | |
31 | Phosphorylation | GWYDADLSPAGHEEA CCCCCCCCCCCHHHH | 17.16 | 22108457 | |
39 | Acetylation | PAGHEEAKRGGQALR CCCHHHHHHHHHHHH | 55.65 | 22902405 | |
50 | Phosphorylation | QALRDAGYEFDICFT HHHHHCCCEEEEECH | 18.36 | - | |
55 | S-nitrosocysteine | AGYEFDICFTSVQKR CCCEEEEECHHHHHH | 3.07 | - | |
55 | S-nitrosylation | AGYEFDICFTSVQKR CCCEEEEECHHHHHH | 3.07 | 22178444 | |
84 | Phosphorylation | MWLPVVRTWRLNERH CHHHHHEEEECCCCC | 11.88 | 22673903 | |
92 | Phosphorylation | WRLNERHYGGLTGLN EECCCCCCCCCCCCC | 21.07 | 29779826 | |
96 | Phosphorylation | ERHYGGLTGLNKAET CCCCCCCCCCCHHHH | 42.78 | 23984901 | |
100 | Ubiquitination | GGLTGLNKAETAAKH CCCCCCCHHHHHHHH | 53.28 | - | |
100 | Acetylation | GGLTGLNKAETAAKH CCCCCCCHHHHHHHH | 53.28 | 182013 | |
106 | Ubiquitination | NKAETAAKHGEAQVK CHHHHHHHHCCCCEE | 50.07 | - | |
106 | Acetylation | NKAETAAKHGEAQVK CHHHHHHHHCCCCEE | 50.07 | 22902405 | |
113 | Ubiquitination | KHGEAQVKIWRRSYD HHCCCCEEEEECCCC | 25.19 | - | |
113 | Acetylation | KHGEAQVKIWRRSYD HHCCCCEEEEECCCC | 25.19 | 22902405 | |
118 | Phosphorylation | QVKIWRRSYDVPPPP CEEEEECCCCCCCCC | 19.67 | 29779826 | |
119 | Phosphorylation | VKIWRRSYDVPPPPM EEEEECCCCCCCCCC | 21.10 | 27097102 | |
138 | Acetylation | PFYSNISKDRRYADL CCCCCCCCCCCCCCC | 52.00 | 22902405 | |
146 | Phosphorylation | DRRYADLTEDQLPSC CCCCCCCCCCCCCCH | 37.75 | 23984901 | |
152 | Phosphorylation | LTEDQLPSCESLKDT CCCCCCCCHHHHHHH | 38.82 | 23984901 | |
153 | S-nitrosylation | TEDQLPSCESLKDTI CCCCCCCHHHHHHHH | 3.78 | 22178444 | |
153 | S-nitrosocysteine | TEDQLPSCESLKDTI CCCCCCCHHHHHHHH | 3.78 | - | |
155 | Phosphorylation | DQLPSCESLKDTIAR CCCCCHHHHHHHHHH | 45.08 | 23984901 | |
157 | Acetylation | LPSCESLKDTIARAL CCCHHHHHHHHHHHC | 63.20 | 22902405 | |
159 | Phosphorylation | SCESLKDTIARALPF CHHHHHHHHHHHCCC | 18.23 | 23984901 | |
176 | Acetylation | EEIVPQIKEGKRVLI CCHHHHHHCCCEEEE | 55.99 | 22902405 | |
189 | Phosphorylation | LIAAHGNSLRGIVKH EEEECCCHHHHHHHH | 24.84 | 23984901 | |
225 | Succinylation | YELDKNLKPIKPMQF EEECCCCCCCCCCCC | 54.83 | 26843850 | |
225 | Acetylation | YELDKNLKPIKPMQF EEECCCCCCCCCCCC | 54.83 | 22902405 | |
228 | Acetylation | DKNLKPIKPMQFLGD CCCCCCCCCCCCCCC | 42.86 | 22902405 | |
238 | Phosphorylation | QFLGDEETVRKAMEA CCCCCHHHHHHHHHH | 24.46 | 22673903 | |
241 | Ubiquitination | GDEETVRKAMEAVAA CCHHHHHHHHHHHHH | 47.99 | - | |
251 | Succinylation | EAVAAQGKVKK---- HHHHHCCCCCC---- | 38.51 | - | |
251 | Succinylation | EAVAAQGKVKK---- HHHHHCCCCCC---- | 38.51 | - | |
251 | Acetylation | EAVAAQGKVKK---- HHHHHCCCCCC---- | 38.51 | - | |
251 | Ubiquitination | EAVAAQGKVKK---- HHHHHCCCCCC---- | 38.51 | - | |
253 | Acetylation | VAAQGKVKK------ HHHCCCCCC------ | 57.14 | - | |
254 | Acetylation | AAQGKVKK------- HHCCCCCC------- | 69.43 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PGAM1_RAT !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
253 | K | Acetylation |
| - |
254 | K | Acetylation |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PGAM1_RAT !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of PGAM1_RAT !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites."; Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.; Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY. |