ATPA_RAT - dbPTM
ATPA_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATPA_RAT
UniProt AC P15999
Protein Name ATP synthase subunit alpha, mitochondrial {ECO:0000305}
Gene Name Atp5f1a {ECO:0000312|RGD:619993}
Organism Rattus norvegicus (Rat).
Sequence Length 553
Subcellular Localization Mitochondrion inner membrane
Peripheral membrane protein
Matrix side . Cell membrane
Peripheral membrane protein
Extracellular side . Colocalizes with HRG on the cell surface of T-cells.
Protein Description Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity)..
Protein Sequence MLSVRIAAAVARALPRRAGLVSKNALGSSFVGTRNLHASNTRLQKTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGDELLGRVVDALGNAIDGKGPVGSKIRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDSFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFESAFLSHVVSQHQSLLGNIRSDGKISEQSDAKLKEIVTNFLAGFEP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3O-linked_Glycosylation-----MLSVRIAAAV
-----CHHHHHHHHH		14.1927213235
28PhosphorylationVSKNALGSSFVGTRN
CCCCCCCCCCCCCCC		22.8127097102
29PhosphorylationSKNALGSSFVGTRNL
CCCCCCCCCCCCCCC		23.3527097102
44Pyrrolidone_carboxylic_acidHASNTRLQKTGTAEM
CCCCCCCCCCCCCCH		37.66-
46PhosphorylationSNTRLQKTGTAEMSS
CCCCCCCCCCCCHHH		27.1423991683
48PhosphorylationTRLQKTGTAEMSSIL
CCCCCCCCCCHHHHH		25.3623991683
52PhosphorylationKTGTAEMSSILEERI
CCCCCCHHHHHHHHH		13.0123991683
52O-linked_GlycosylationKTGTAEMSSILEERI
CCCCCCHHHHHHHHH		13.0127213235
53PhosphorylationTGTAEMSSILEERIL
CCCCCHHHHHHHHHC		29.8629779826
64PhosphorylationERILGADTSVDLEET
HHHCCCCCEECHHHH		30.0727097102
64O-linked_GlycosylationERILGADTSVDLEET
HHHCCCCCEECHHHH		30.0727213235
65PhosphorylationRILGADTSVDLEETG
HHCCCCCEECHHHHC		17.7427097102
65O-linked_GlycosylationRILGADTSVDLEETG
HHCCCCCEECHHHHC		17.7427213235
71PhosphorylationTSVDLEETGRVLSIG
CEECHHHHCCEEEEC		22.4028432305
76O-linked_GlycosylationEETGRVLSIGDGIAR
HHHCCEEEECCCHHH		22.9727213235
76PhosphorylationEETGRVLSIGDGIAR
HHHCCEEEECCCHHH		22.9727097102
106PhosphorylationSSGLKGMSLNLEPDN
CCCCCCCCCCCCCCC		23.83-
123AcetylationVVVFGNDKLIKEGDI
EEEECCCCEECCCCC		56.9922902405
126AcetylationFGNDKLIKEGDIVKR
ECCCCEECCCCCCCC		67.1122902405
126SuccinylationFGNDKLIKEGDIVKR
ECCCCEECCCCCCCC		67.1126843850
132AcetylationIKEGDIVKRTGAIVD
ECCCCCCCCCCCEEE		44.5722902405
132SuccinylationIKEGDIVKRTGAIVD
ECCCCCCCCCCCEEE		44.5726843850
134PhosphorylationEGDIVKRTGAIVDVP
CCCCCCCCCCEEEEE		25.8322673903
161SuccinylationLGNAIDGKGPVGSKI
HHHHHCCCCCCCHHH		57.18-
161AcetylationLGNAIDGKGPVGSKI
HHHHHCCCCCCCHHH		57.1822902405
161SuccinylationLGNAIDGKGPVGSKI
HHHHHCCCCCCCHHH		57.18-
166PhosphorylationDGKGPVGSKIRRRVG
CCCCCCCHHHHHHHC		25.7428689409
166O-linked_GlycosylationDGKGPVGSKIRRRVG
CCCCCCCHHHHHHHC		25.7427213235
167AcetylationGKGPVGSKIRRRVGL
CCCCCCHHHHHHHCC		34.0125786129
167SuccinylationGKGPVGSKIRRRVGL
CCCCCCHHHHHHHCC		34.01-
167SuccinylationGKGPVGSKIRRRVGL
CCCCCCHHHHHHHCC		34.01-
175UbiquitinationIRRRVGLKAPGIIPR
HHHHHCCCCCCCCCC		46.75-
175AcetylationIRRRVGLKAPGIIPR
HHHHHCCCCCCCCCC		46.7522902405
184PhosphorylationPGIIPRISVREPMQT
CCCCCCEECCCCCCC		19.1928689409
184O-linked_GlycosylationPGIIPRISVREPMQT
CCCCCCEECCCCCCC		19.1927213235
194AcetylationEPMQTGIKAVDSLVP
CCCCCCCCHHHHCCC		43.6422902405
198PhosphorylationTGIKAVDSLVPIGRG
CCCCHHHHCCCCCCC		25.3528689409
198O-linked_GlycosylationTGIKAVDSLVPIGRG
CCCCHHHHCCCCCCC		25.3527213235
204MethylationDSLVPIGRGQRELII
HHCCCCCCCCCEEEE		38.50-
219O-linked_GlycosylationGDRQTGKTSIAIDTI
ECCCCCCEEEEHHHH		27.0627213235
230SuccinylationIDTIINQKRFNDGTD
HHHHHCCCCCCCCCC		55.24-
230AcetylationIDTIINQKRFNDGTD
HHHHHCCCCCCCCCC		55.2422902405
230SuccinylationIDTIINQKRFNDGTD
HHHHHCCCCCCCCCC		55.24-
236PhosphorylationQKRFNDGTDEKKKLY
CCCCCCCCCHHCEEE		43.8023991683
239SuccinylationFNDGTDEKKKLYCIY
CCCCCCHHCEEEEEE		59.00-
239AcetylationFNDGTDEKKKLYCIY
CCCCCCHHCEEEEEE		59.0022902405
239SuccinylationFNDGTDEKKKLYCIY
CCCCCCHHCEEEEEE		59.00-
240AcetylationNDGTDEKKKLYCIYV
CCCCCHHCEEEEEEE		46.0622902405
241AcetylationDGTDEKKKLYCIYVA
CCCCHHCEEEEEEEE		56.6126302492
243PhosphorylationTDEKKKLYCIYVAIG
CCHHCEEEEEEEECC		5.91-
261AcetylationSTVAQLVKRLTDADA
HHHHHHHHHCCHHHH		50.7322902405
261SuccinylationSTVAQLVKRLTDADA
HHHHHHHHHCCHHHH		50.73-
261SuccinylationSTVAQLVKRLTDADA
HHHHHHHHHCCHHHH		50.73-
264PhosphorylationAQLVKRLTDADAMKY
HHHHHHCCHHHHCCE		32.9223991683
305AcetylationEYFRDNGKHALIIYD
HHHHHCCCEEEEEEE		31.7722902405
305SuccinylationEYFRDNGKHALIIYD
HHHHHCCCEEEEEEE		31.77-
305SuccinylationEYFRDNGKHALIIYD
HHHHHCCCEEEEEEE		31.77-
315O-linked_GlycosylationLIIYDDLSKQAVAYR
EEEEECHHHHHHHHH		29.7127213235
316AcetylationIIYDDLSKQAVAYRQ
EEEECHHHHHHHHHH		49.9622902405
325O-linked_GlycosylationAVAYRQMSLLLRRPP
HHHHHHHHHHHCCCC		13.9227213235
337PhosphorylationRPPGREAYPGDVFYL
CCCCCCCCCCCHHHH		11.7328689409
343PhosphorylationAYPGDVFYLHSRLLE
CCCCCHHHHHHHHHH		11.8928689409
346O-linked_GlycosylationGDVFYLHSRLLERAA
CCHHHHHHHHHHHHH		23.2527213235
346PhosphorylationGDVFYLHSRLLERAA
CCHHHHHHHHHHHHH		23.2528689409
413O-linked_GlycosylationPAINVGLSVSRVGSA
HHHCCCCCHHHCCHH		16.4727213235
419PhosphorylationLSVSRVGSAAQTRAM
CCHHHCCHHHHHHHH		19.9923991683
427SuccinylationAAQTRAMKQVAGTMK
HHHHHHHHHHHHCHH		40.4126843850
427AcetylationAAQTRAMKQVAGTMK
HHHHHHHHHHHHCHH		40.4122902405
427SuccinylationAAQTRAMKQVAGTMK
HHHHHHHHHHHHCHH		40.41-
434AcetylationKQVAGTMKLELAQYR
HHHHHCHHHHHHHHH		38.3522902405
451PhosphorylationAAFAQFGSDLDAATQ
HHHHCCCCCHHHHHH		35.9722673903
451O-linked_GlycosylationAAFAQFGSDLDAATQ
HHHHCCCCCHHHHHH		35.9727213235
457PhosphorylationGSDLDAATQQLLSRG
CCCHHHHHHHHHHHC		20.6923984901
498AcetylationGVRGYLDKLEPSKIT
HHHHHHHHCCHHHCH		52.7522902405
498SuccinylationGVRGYLDKLEPSKIT
HHHHHHHHCCHHHCH		52.7526843850
498SuccinylationGVRGYLDKLEPSKIT
HHHHHHHHCCHHHCH		52.75-
502PhosphorylationYLDKLEPSKITKFES
HHHHCCHHHCHHHHH		27.5823991683
502O-linked_GlycosylationYLDKLEPSKITKFES
HHHHCCHHHCHHHHH		27.5827213235
503AcetylationLDKLEPSKITKFESA
HHHCCHHHCHHHHHH		66.1722902405
505PhosphorylationKLEPSKITKFESAFL
HCCHHHCHHHHHHHH		33.1623991683
506SuccinylationLEPSKITKFESAFLS
CCHHHCHHHHHHHHH		51.08-
506SuccinylationLEPSKITKFESAFLS
CCHHHCHHHHHHHHH		51.08-
506AcetylationLEPSKITKFESAFLS
CCHHHCHHHHHHHHH		51.0822902405
509PhosphorylationSKITKFESAFLSHVV
HHCHHHHHHHHHHHH		27.7028689409
513PhosphorylationKFESAFLSHVVSQHQ
HHHHHHHHHHHHHHH		14.0523991683
513O-linked_GlycosylationKFESAFLSHVVSQHQ
HHHHHHHHHHHHHHH		14.0527213235
517PhosphorylationAFLSHVVSQHQSLLG
HHHHHHHHHHHHHHC		22.3627097102
517O-linked_GlycosylationAFLSHVVSQHQSLLG
HHHHHHHHHHHHHHC		22.3627213235
521PhosphorylationHVVSQHQSLLGNIRS
HHHHHHHHHHCCCCC		24.3627097102
528PhosphorylationSLLGNIRSDGKISEQ
HHHCCCCCCCCCCCC		47.0923991683
531SuccinylationGNIRSDGKISEQSDA
CCCCCCCCCCCCCHH		48.31-
531AcetylationGNIRSDGKISEQSDA
CCCCCCCCCCCCCHH		48.3125786129
531SuccinylationGNIRSDGKISEQSDA
CCCCCCCCCCCCCHH		48.3126843850
533PhosphorylationIRSDGKISEQSDAKL
CCCCCCCCCCCHHHH		32.8223991683
533O-linked_GlycosylationIRSDGKISEQSDAKL
CCCCCCCCCCCHHHH		32.8227213235
536PhosphorylationDGKISEQSDAKLKEI
CCCCCCCCHHHHHHH		35.1723991683
539SuccinylationISEQSDAKLKEIVTN
CCCCCHHHHHHHHHH		66.1526843850
539AcetylationISEQSDAKLKEIVTN
CCCCCHHHHHHHHHH		66.1525786129
539SuccinylationISEQSDAKLKEIVTN
CCCCCHHHHHHHHHH		66.15-
541AcetylationEQSDAKLKEIVTNFL
CCCHHHHHHHHHHHH		44.6922902405
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATPA_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATPA_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATPA_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ATPA_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATPA_RAT

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Related Literatures of Post-Translational Modification

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