ROA2_RAT - dbPTM
ROA2_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ROA2_RAT
UniProt AC A7VJC2
Protein Name Heterogeneous nuclear ribonucleoproteins A2/B1 {ECO:0000312|EMBL:BAF79676.1}
Gene Name Hnrnpa2b1 {ECO:0000250|UniProtKB:P22626}
Organism Rattus norvegicus (Rat).
Sequence Length 353
Subcellular Localization Isoform B1: Nucleus .
Isoform A2: Nucleus .
Isoform A2b: Cytoplasm . Nucleus . Mainly localizes in the cytoplasm in neural cells.
Isoform B1b: Cytoplasm . Nucleus .
Nucleus, nucleoplasm . Cytoplasm . Cytoplasmic granule . Secreted, exosome . Note
Protein Description Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. [PubMed: 19099192 Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm]
Protein Sequence MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIFLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEKTLETV
-------CCCCCCCC		12.2924098712
3Acetylation-----MEKTLETVPL
-----CCCCCCCCCC		58.0522902405
4Phosphorylation----MEKTLETVPLE
----CCCCCCCCCCH		19.27-
29PhosphorylationKLFIGGLSFETTEES
HHHCCCCCCCCCHHH		25.0627097102
32PhosphorylationIGGLSFETTEESLRN
CCCCCCCCCHHHHHH		37.1827097102
33PhosphorylationGGLSFETTEESLRNY
CCCCCCCCHHHHHHH		30.4727097102
38MethylationETTEESLRNYYEQWG
CCCHHHHHHHHHHHC		38.08-
41PhosphorylationEESLRNYYEQWGKLT
HHHHHHHHHHHCCCE		12.75-
59AcetylationVMRDPASKRSRGFGF
EECCCCCCCCCCCEE		57.4022902405
61PhosphorylationRDPASKRSRGFGFVT
CCCCCCCCCCCEEEE		40.2623712012
68PhosphorylationSRGFGFVTFSSMAEV
CCCCEEEEEHHHHHH		18.6223712012
85PhosphorylationAMAARPHSIDGRVVE
HHHCCCCCCCCEECC		25.6724972320
102PhosphorylationRAVAREESGKPGAHV
CHHHHHHCCCCCCEE		47.5722673903
104SuccinylationVAREESGKPGAHVTV
HHHHHCCCCCCEEEE		49.9426843850
104"N6,N6-dimethyllysine"VAREESGKPGAHVTV
HHHHHCCCCCCEEEE		49.94-
104MethylationVAREESGKPGAHVTV
HHHHHCCCCCCEEEE		49.94-
104AcetylationVAREESGKPGAHVTV
HHHHHCCCCCCEEEE		49.9422902405
112UbiquitinationPGAHVTVKKLFVGGI
CCCEEEEEEEEECCC		34.10-
112AcetylationPGAHVTVKKLFVGGI
CCCEEEEEEEEECCC		34.1025786129
120AcetylationKLFVGGIKEDTEEHH
EEEECCCCCCCCHHH		53.4622902405
137UbiquitinationDYFEEYGKIDTIEII
HHHHHHCCCCEEEEE		36.19-
140PhosphorylationEEYGKIDTIEIITDR
HHHCCCCEEEEEECC		24.79-
149PhosphorylationEIITDRQSGKKRGFG
EEEECCCCCCCCEEE		54.1723984901
159PhosphorylationKRGFGFVTFDDHDPV
CCEEEEEECCCCCCC		21.0523984901
168AcetylationDDHDPVDKIFLQKYH
CCCCCCHHHHHEEEC		35.28-
173AcetylationVDKIFLQKYHTINGH
CHHHHHEEECHHCCC		40.94-
176PhosphorylationIFLQKYHTINGHNAE
HHHEEECHHCCCCHH		17.0423984901
189PhosphorylationAEVRKALSRQEMQEV
HHHHHHHCHHHHHHH		36.4623984901
198PhosphorylationQEMQEVQSSRSGRGG
HHHHHHHHHCCCCCC		32.6622108457
201PhosphorylationQEVQSSRSGRGGNFG
HHHHHHCCCCCCCCC		34.4923984901
203Asymmetric dimethylarginineVQSSRSGRGGNFGFG
HHHHCCCCCCCCCCC		51.60-
203MethylationVQSSRSGRGGNFGFG
HHHHCCCCCCCCCCC		51.60-
212PhosphorylationGNFGFGDSRGGGGNF
CCCCCCCCCCCCCCC		32.9527097102
213Asymmetric dimethylarginineNFGFGDSRGGGGNFG
CCCCCCCCCCCCCCC		53.14-
213MethylationNFGFGDSRGGGGNFG
CCCCCCCCCCCCCCC		53.14-
225PhosphorylationNFGPGPGSNFRGGSD
CCCCCCCCCCCCCCC		35.6127097102
228MethylationPGPGSNFRGGSDGYG
CCCCCCCCCCCCCCC		53.46-
231PhosphorylationGSNFRGGSDGYGSGR
CCCCCCCCCCCCCCC		30.5929779826
234PhosphorylationFRGGSDGYGSGRGFG
CCCCCCCCCCCCCCC		17.0723984901
236PhosphorylationGGSDGYGSGRGFGDG
CCCCCCCCCCCCCCC		19.4823984901
238MethylationSDGYGSGRGFGDGYN
CCCCCCCCCCCCCCC		38.68-
244PhosphorylationGRGFGDGYNGYGGGP
CCCCCCCCCCCCCCC		15.3421630457
247PhosphorylationFGDGYNGYGGGPGGG
CCCCCCCCCCCCCCC		14.6823984901
259PhosphorylationGGGNFGGSPGYGGGR
CCCCCCCCCCCCCCC		18.6123712012
262PhosphorylationNFGGSPGYGGGRGGY
CCCCCCCCCCCCCCC		18.9123984901
266Asymmetric dimethylarginineSPGYGGGRGGYGGGG
CCCCCCCCCCCCCCC		38.34-
266MethylationSPGYGGGRGGYGGGG
CCCCCCCCCCCCCCC		38.3424098712
318PhosphorylationSNYGPMKSGNFGGSR
CCCCCCCCCCCCCCC		32.4923984901
324PhosphorylationKSGNFGGSRNMGGPY
CCCCCCCCCCCCCCC		22.3623984901
325MethylationSGNFGGSRNMGGPYG
CCCCCCCCCCCCCCC		40.19-
331PhosphorylationSRNMGGPYGGGNYGP
CCCCCCCCCCCCCCC		31.5128432305
336PhosphorylationGPYGGGNYGPGGSGG
CCCCCCCCCCCCCCC		28.1528432305
341PhosphorylationGNYGPGGSGGSGGYG
CCCCCCCCCCCCCCC		45.9927097102
344PhosphorylationGPGGSGGSGGYGGRS
CCCCCCCCCCCCCCC		32.3527097102
347PhosphorylationGSGGSGGYGGRSRY-
CCCCCCCCCCCCCC-		21.6727097102
350MethylationGSGGYGGRSRY----
CCCCCCCCCCC----		17.38-
351PhosphorylationSGGYGGRSRY-----
CCCCCCCCCC-----		38.9223984901
353PhosphorylationGYGGRSRY-------
CCCCCCCC-------		24.9323984901
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ROA2_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
266RMethylation

24098712
266RMethylation

24098712
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ROA2_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ROA2_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ROA2_RAT

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Related Literatures of Post-Translational Modification

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