RAP1A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAP1A_RAT
• UniProt AC: P62836
• Protein Name: Ras-related protein Rap-1A
• Gene Name: Rap1a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 184
• Subcellular Localization: Cell membrane; Lipid-anchor. Cytoplasm, perinuclear region . Early endosome . Late endosome . Cytoplasm. Cell junction. Localized with RAPGEF2 at cell-cell junctions. Colocalized with RAPGEF2 in the perinuclear region (By similarity). Recruited from
• Protein Description: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions..
• Protein Sequence: MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MREYKLVVLGSG ---CCEEEEEEECCC	30.01	22902405
17	Phosphorylation	GSGGVGKSALTVQFV CCCCCCCHHHHHHEE	23.68	-
31	Ubiquitination	VQGIFVEKYDPTIED EEEEEEEECCCCCCH	50.04	-
39	Phosphorylation	YDPTIEDSYRKQVEV CCCCCCHHHHHHCEE	17.66	30181290
151	Acetylation	LESSAKSKINVNEIF HHHHCCCCCCHHHHH	37.28	22902405
159	Phosphorylation	INVNEIFYDLVRQIN CCHHHHHHHHHHHHH	17.65	-
181	Methylation	KKPKKKSCLLL---- CCCCCCCCCCC----	4.22	-
181	Geranylgeranylation	KKPKKKSCLLL---- CCCCCCCCCCC----	4.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAP1A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAP1A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAP1A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RAP1A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.