FSCN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FSCN1_RAT
• UniProt AC: P85845
• Protein Name: Fascin
• Gene Name: Fscn1 {ECO:0000250|UniProtKB:Q16658}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 493
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Cell projection, growth cone . Cell projection, filopodium . Cell projection, invadopodium . Cell projection, microvillus . Cell junction . Colocalized with RUFY3 and F-actin at filipodia of the axonal g
• Protein Description: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility..
• Protein Sequence: MTANGTAEAVQIQFGLISCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGPYLAADKDGNVTCEREVPDGDCRFLVVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQSVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTSDHRFLRHDGRLVARPEPATGFTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTRKCAFRTHTGKYWTLTATGGVQSTASTKNASCYFDIEWCERRITLRASNGKFVTAKKNGQLAATVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSSVTSSSDTPVDFFLEFCDYNKVALKVGGRYLKGDHAGVLKACAETIDPATLWEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTANGTAEA ------CCCCCCEEE	28.91	-
36	Phosphorylation	FGFKVNASASSLKKK HCCEEECCCHHHCCC	24.39	23984901
38	Phosphorylation	FKVNASASSLKKKQI CEEECCCHHHCCCEE	33.44	27097102
39	Phosphorylation	KVNASASSLKKKQIW EEECCCHHHCCCEEE	43.88	23984901
74	Acetylation	GPYLAADKDGNVTCE CCCCCCCCCCCEEEE	63.91	-
105	Phosphorylation	DGRWSLQSEAHRRYF CCCEEECCHHHHHHC	41.88	27097102
111	Phosphorylation	QSEAHRRYFGGTEDR CCHHHHHHCCCCCHH	13.41	23984901
115	Phosphorylation	HRRYFGGTEDRLSCF HHHHCCCCCHHHHHH	34.78	23984901
120	Phosphorylation	GGTEDRLSCFAQSVS CCCCHHHHHHEEECC	14.21	23984901
125	Phosphorylation	RLSCFAQSVSPAEKW HHHHHEEECCHHHHC	22.57	27097102
127	Phosphorylation	SCFAQSVSPAEKWSV HHHEEECCHHHHCEE	24.52	27097102
213	Phosphorylation	PEPATGFTLEFRSGK CCCCCCEEEEECCCC	27.07	23984901
234	Phosphorylation	EGRYLAPSGPSGTLK CCCEECCCCCCCCEE	58.70	23984901
237	Phosphorylation	YLAPSGPSGTLKAGK EECCCCCCCCEECCC	48.19	23984901
239	Phosphorylation	APSGPSGTLKAGKAT CCCCCCCCEECCCEE	29.44	23984901
241	Acetylation	SGPSGTLKAGKATKV CCCCCCEECCCEEEC	55.73	25786129
353	Acetylation	TLRASNGKFVTAKKN EEEECCCCEEEEEEC	40.69	22902405
399	Ubiquitination	HGFIGCRKVTGTLDA CCEECEEEEEEEEEC	48.50	-
401	Phosphorylation	FIGCRKVTGTLDANR EECEEEEEEEEECCC	27.73	25403869
403	Phosphorylation	GCRKVTGTLDANRSS CEEEEEEEEECCCCC	16.46	27097102
471	Acetylation	KVGGRYLKGDHAGVL EECCEECCCCCHHHH	54.05	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
39	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
39	S	Phosphorylation	Phosphorylation at Ser-39 inhibits actin-binding.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FSCN1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of FSCN1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.